Twenty Years' Delay of Fellow Eye Involvement in Herpes Simplex Virus Type 2-Associated Bilateral Acute Retinal Necrosis Syndrome

To describe a case of acute retinal necrosis with concurrent encephalitis and determine the causative virus. The patient had a history of presumed acute retinal necrosis in the left eye at the age of 8 years and recurrent genital herpes. Diagnostic anterior chamber puncture of the eye and lumbar pun...

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Bibliographic Details
Published in:American journal of ophthalmology 1996-12, Vol.122 (6), p.891-892
Main Authors: Schlingemann, R.O., Bruinenberg, M., Dillen, P. Wertheim-van, Feron, E.
Format: Article
Language:English
Subjects:
Acyclovir - therapeutic use
Adult
Antibodies, Viral - analysis
Antiviral Agents - therapeutic use
Aqueous Humor - virology
Biological and medical sciences
Cerebrospinal Fluid - virology
Combined Modality Therapy
DNA, Viral - analysis
Encephalitis, Viral - diagnosis
Encephalitis, Viral - etiology
Encephalitis, Viral - therapy
Eye Infections, Viral - diagnosis
Eye Infections, Viral - etiology
Eye Infections, Viral - therapy
Female
Fluorescein Angiography
Fundus Oculi
Herpes Genitalis - etiology
Herpes Simplex - diagnosis
Herpes Simplex - etiology
Herpes Simplex - therapy
Herpesvirus 2, Human - genetics
Herpesvirus 2, Human - immunology
Herpesvirus 2, Human - isolation & purification
Human viral diseases
Humans
Infectious diseases
Laser Therapy
Medical sciences
Polymerase Chain Reaction
Recurrence
Retinal Necrosis Syndrome, Acute - diagnosis
Retinal Necrosis Syndrome, Acute - therapy
Retinal Necrosis Syndrome, Acute - virology
Viral diseases
Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
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Summary:To describe a case of acute retinal necrosis with concurrent encephalitis and determine the causative virus. The patient had a history of presumed acute retinal necrosis in the left eye at the age of 8 years and recurrent genital herpes. Diagnostic anterior chamber puncture of the eye and lumbar puncture for laboratory analysis. Polymerase chain reaction identified herpes simplex virus type 2 in the eye, and local antibody production to herpes simplex virus was demonstrated in the aqueous of this eye and in the cerebrospinal fluid. Herpes simplex virus type 2 may cause bilateral acute retinal necrosis with long delay of fellow eye involvement and concurrent encephalitis.
ISSN:0002-9394
1879-1891
DOI:10.1016/S0002-9394(14)70390-3