CnNK-2,an NK-2 Homeobox Gene, Has a Role in Patterning the Basal End of the Axis in Hydra

NK-2-class homeobox genes have been identified in a variety of metazoans, from sponges to arthropods and vertebrates, and have been shown to play roles in a variety of cell and tissue specifications. Here we describe the characterization of the NK-2 homologCnNK-2fromHydra vulgaris,a freshwater cnida...

Full description

Saved in:
Bibliographic Details
Published in:Developmental biology 1996-12, Vol.180 (2), p.473-488
Main Authors: Grens, Ann, Gee, Lydia, Fisher, Douglas A., Bode, Hans R.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Base Sequence
Drosophila
Drosophila Proteins
Gene Expression Regulation, Developmental
Genes, Homeobox
Homeodomain Proteins - biosynthesis
Homeodomain Proteins - chemistry
Homeodomain Proteins - genetics
Hydra - genetics
Hydra - physiology
In Situ Hybridization
Mice
Molecular Sequence Data
Rats
Regeneration
Sequence Homology, Amino Acid
Transcription Factors
Xenopus
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:NK-2-class homeobox genes have been identified in a variety of metazoans, from sponges to arthropods and vertebrates, and have been shown to play roles in a variety of cell and tissue specifications. Here we describe the characterization of the NK-2 homologCnNK-2fromHydra vulgaris,a freshwater cnidarian.CnNK-2expression is restricted to the endodermal epithelial cells of hydra and is primarily in the peduncle, the lower end of the body column. In some species it is graded along the apical–basal axis with a maximum in the basal tissue of the lower peduncle, adjacent to the foot.CnNK-2expression invariably precedes foot formation as part of the normal tissue dynamics of the adult as well as during asexual reproduction by budding, foot regeneration, or ectopic foot formation. Manipulations which alter the gradient of positional value along this axis affectCnNK-2expression in a manner which indicates that expression of this gene is closely linked to the gradient. The normal and altered patterns of expression of this gene extend the understanding of the regulation of foot formation in hydra.
ISSN:0012-1606
1095-564X
DOI:10.1006/dbio.1996.0321