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Immunohistochemical evaluation of p53 oncoprotein in transitional cell carcinoma of the upper urinary tract

The p53 gene, which is located on human chromosome 17, encodes for a nuclear phosphoprotein and is thought to regulate cell growth and proliferation. Although the immunoreactivity for p53 oncoprotein in transitional cell carcinoma (TCC) of the urinary bladder has been shown to correlate with clinico...

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Published in:Human pathology 1996-12, Vol.27 (12), p.1336-1340
Main Authors: Nakanishi, Kuniaki, Kawai, Toshiaki, Torikata, Chikao
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description The p53 gene, which is located on human chromosome 17, encodes for a nuclear phosphoprotein and is thought to regulate cell growth and proliferation. Although the immunoreactivity for p53 oncoprotein in transitional cell carcinoma (TCC) of the urinary bladder has been shown to correlate with clinicopathologic findings and prognoses, there have been no such reports on TCC of the upper urinary tract (TCC-UUT). The present study investigated the prognostic value of p53 oncoprotein in TCC-UUT. Formalin-fixed, paraffin-embedded tumor tissues from 149 TCC-UUT patients were analyzed using immunohistochemical staining. Immunohistochemically, p53 oncoprotein was recognized as positive in 26.8% of the samples. The immunoreactivity for p53 oncoprotein was significantly ( P < .05) correlated with both stage, grade, and pattern of growth. The 5-year disease-free and overall survival rates were 58.4% and 69.7%, respectively. A univariate analysis of survival showed that stage, grade, pattern of growth, and the immunoreactivity for p53 oncoprotein have a significant effect on disease-free and overall survival rates. In the final models of multivariate analysis, only stage for disease-free survival, and stage and the immunoreactivity for p53 oncoprotein for overall survival were found to be progressive or prognostic factors. Detection of immunoreactivity for p53 oncoprotein appears to be of real value in deciding the prognosis of TCC-UUT.
doi_str_mv 10.1016/S0046-8177(96)90347-0
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Urinary tract diseases</subject><subject>p53 oncoprotein</subject><subject>Prognosis</subject><subject>Survival Rate</subject><subject>transitional cell carcinoma</subject><subject>Tumor Suppressor Protein p53 - biosynthesis</subject><subject>Tumor Suppressor Protein p53 - immunology</subject><subject>Tumors of the urinary system</subject><subject>upper urinary tract</subject><subject>Urinary tract. 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Urinary tract diseases</topic><topic>p53 oncoprotein</topic><topic>Prognosis</topic><topic>Survival Rate</topic><topic>transitional cell carcinoma</topic><topic>Tumor Suppressor Protein p53 - biosynthesis</topic><topic>Tumor Suppressor Protein p53 - immunology</topic><topic>Tumors of the urinary system</topic><topic>upper urinary tract</topic><topic>Urinary tract. Prostate gland</topic><topic>Urologic Neoplasms - chemistry</topic><topic>Urologic Neoplasms - mortality</topic><topic>Urologic Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakanishi, Kuniaki</creatorcontrib><creatorcontrib>Kawai, Toshiaki</creatorcontrib><creatorcontrib>Torikata, Chikao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakanishi, Kuniaki</au><au>Kawai, Toshiaki</au><au>Torikata, Chikao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical evaluation of p53 oncoprotein in transitional cell carcinoma of the upper urinary tract</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>27</volume><issue>12</issue><spage>1336</spage><epage>1340</epage><pages>1336-1340</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>The p53 gene, which is located on human chromosome 17, encodes for a nuclear phosphoprotein and is thought to regulate cell growth and proliferation. 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identifier ISSN: 0046-8177
ispartof Human pathology, 1996-12, Vol.27 (12), p.1336-1340
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source ScienceDirect Journals
subjects Aged
Biological and medical sciences
Carcinoma, Transitional Cell - chemistry
Carcinoma, Transitional Cell - mortality
Carcinoma, Transitional Cell - pathology
Female
Humans
Immunohistochemistry
Male
Medical sciences
Middle Aged
Multivariate Analysis
Nephrology. Urinary tract diseases
p53 oncoprotein
Prognosis
Survival Rate
transitional cell carcinoma
Tumor Suppressor Protein p53 - biosynthesis
Tumor Suppressor Protein p53 - immunology
Tumors of the urinary system
upper urinary tract
Urinary tract. Prostate gland
Urologic Neoplasms - chemistry
Urologic Neoplasms - mortality
Urologic Neoplasms - pathology
title Immunohistochemical evaluation of p53 oncoprotein in transitional cell carcinoma of the upper urinary tract
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