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Immunohistochemical evaluation of p53 oncoprotein in transitional cell carcinoma of the upper urinary tract
The p53 gene, which is located on human chromosome 17, encodes for a nuclear phosphoprotein and is thought to regulate cell growth and proliferation. Although the immunoreactivity for p53 oncoprotein in transitional cell carcinoma (TCC) of the urinary bladder has been shown to correlate with clinico...
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Published in: | Human pathology 1996-12, Vol.27 (12), p.1336-1340 |
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description | The p53 gene, which is located on human chromosome 17, encodes for a nuclear phosphoprotein and is thought to regulate cell growth and proliferation. Although the immunoreactivity for p53 oncoprotein in transitional cell carcinoma (TCC) of the urinary bladder has been shown to correlate with clinicopathologic findings and prognoses, there have been no such reports on TCC of the upper urinary tract (TCC-UUT). The present study investigated the prognostic value of p53 oncoprotein in TCC-UUT. Formalin-fixed, paraffin-embedded tumor tissues from 149 TCC-UUT patients were analyzed using immunohistochemical staining. Immunohistochemically, p53 oncoprotein was recognized as positive in 26.8% of the samples. The immunoreactivity for p53 oncoprotein was significantly (
P < .05) correlated with both stage, grade, and pattern of growth. The 5-year disease-free and overall survival rates were 58.4% and 69.7%, respectively. A univariate analysis of survival showed that stage, grade, pattern of growth, and the immunoreactivity for p53 oncoprotein have a significant effect on disease-free and overall survival rates. In the final models of multivariate analysis, only stage for disease-free survival, and stage and the immunoreactivity for p53 oncoprotein for overall survival were found to be progressive or prognostic factors. Detection of immunoreactivity for p53 oncoprotein appears to be of real value in deciding the prognosis of TCC-UUT. |
doi_str_mv | 10.1016/S0046-8177(96)90347-0 |
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P < .05) correlated with both stage, grade, and pattern of growth. The 5-year disease-free and overall survival rates were 58.4% and 69.7%, respectively. A univariate analysis of survival showed that stage, grade, pattern of growth, and the immunoreactivity for p53 oncoprotein have a significant effect on disease-free and overall survival rates. In the final models of multivariate analysis, only stage for disease-free survival, and stage and the immunoreactivity for p53 oncoprotein for overall survival were found to be progressive or prognostic factors. Detection of immunoreactivity for p53 oncoprotein appears to be of real value in deciding the prognosis of TCC-UUT.</description><identifier>ISSN: 0046-8177</identifier><identifier>EISSN: 1532-8392</identifier><identifier>DOI: 10.1016/S0046-8177(96)90347-0</identifier><identifier>PMID: 8958308</identifier><identifier>CODEN: HPCQA4</identifier><language>eng</language><publisher>New York, NY: Elsevier Inc</publisher><subject>Aged ; Biological and medical sciences ; Carcinoma, Transitional Cell - chemistry ; Carcinoma, Transitional Cell - mortality ; Carcinoma, Transitional Cell - pathology ; Female ; Humans ; Immunohistochemistry ; Male ; Medical sciences ; Middle Aged ; Multivariate Analysis ; Nephrology. Urinary tract diseases ; p53 oncoprotein ; Prognosis ; Survival Rate ; transitional cell carcinoma ; Tumor Suppressor Protein p53 - biosynthesis ; Tumor Suppressor Protein p53 - immunology ; Tumors of the urinary system ; upper urinary tract ; Urinary tract. Prostate gland ; Urologic Neoplasms - chemistry ; Urologic Neoplasms - mortality ; Urologic Neoplasms - pathology</subject><ispartof>Human pathology, 1996-12, Vol.27 (12), p.1336-1340</ispartof><rights>1996</rights><rights>1997 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c484t-64b2eb56561760f869bee273b15bbf44cffe3bb80f53ac5a3009e567b42451653</citedby><cites>FETCH-LOGICAL-c484t-64b2eb56561760f869bee273b15bbf44cffe3bb80f53ac5a3009e567b42451653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2535495$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8958308$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Nakanishi, Kuniaki</creatorcontrib><creatorcontrib>Kawai, Toshiaki</creatorcontrib><creatorcontrib>Torikata, Chikao</creatorcontrib><title>Immunohistochemical evaluation of p53 oncoprotein in transitional cell carcinoma of the upper urinary tract</title><title>Human pathology</title><addtitle>Hum Pathol</addtitle><description>The p53 gene, which is located on human chromosome 17, encodes for a nuclear phosphoprotein and is thought to regulate cell growth and proliferation. Although the immunoreactivity for p53 oncoprotein in transitional cell carcinoma (TCC) of the urinary bladder has been shown to correlate with clinicopathologic findings and prognoses, there have been no such reports on TCC of the upper urinary tract (TCC-UUT). The present study investigated the prognostic value of p53 oncoprotein in TCC-UUT. Formalin-fixed, paraffin-embedded tumor tissues from 149 TCC-UUT patients were analyzed using immunohistochemical staining. Immunohistochemically, p53 oncoprotein was recognized as positive in 26.8% of the samples. The immunoreactivity for p53 oncoprotein was significantly (
P < .05) correlated with both stage, grade, and pattern of growth. The 5-year disease-free and overall survival rates were 58.4% and 69.7%, respectively. A univariate analysis of survival showed that stage, grade, pattern of growth, and the immunoreactivity for p53 oncoprotein have a significant effect on disease-free and overall survival rates. In the final models of multivariate analysis, only stage for disease-free survival, and stage and the immunoreactivity for p53 oncoprotein for overall survival were found to be progressive or prognostic factors. Detection of immunoreactivity for p53 oncoprotein appears to be of real value in deciding the prognosis of TCC-UUT.</description><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Carcinoma, Transitional Cell - chemistry</subject><subject>Carcinoma, Transitional Cell - mortality</subject><subject>Carcinoma, Transitional Cell - pathology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Nephrology. Urinary tract diseases</subject><subject>p53 oncoprotein</subject><subject>Prognosis</subject><subject>Survival Rate</subject><subject>transitional cell carcinoma</subject><subject>Tumor Suppressor Protein p53 - biosynthesis</subject><subject>Tumor Suppressor Protein p53 - immunology</subject><subject>Tumors of the urinary system</subject><subject>upper urinary tract</subject><subject>Urinary tract. Prostate gland</subject><subject>Urologic Neoplasms - chemistry</subject><subject>Urologic Neoplasms - mortality</subject><subject>Urologic Neoplasms - pathology</subject><issn>0046-8177</issn><issn>1532-8392</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNqFkM1KJDEUhYOMaOv4CEItZNBFjUnlp1IrEZkfQZjFOOuQpG_ozHQlZZISfHtTdtPbgZAs7nduDh9ClwR_JZiI298YM9FK0vfXg7gZMGV9i4_QinDatZIO3Se0OiCn6CznvxgTwhk_QSdy4JJiuUL_HsdxDnHjc4l2A6O3etvAq97OuvgYmuiaidMmBhunFAv40NRTkg7ZL0ClLWzrpZP1IY56SZQNNPM0QWrm5INOb0vAls_o2Olthov9e47-fP_2_PCzffr14_Hh_qm1TLLSCmY6MFxwQXqBnRSDAeh6agg3xjFmnQNqjMSOU225phgPwEVvWMc4EZyeoy-7vbXxywy5qNHnpaUOEOeselk3Y04ryHegTTHnBE5NyY-1ryJYLZLVh2S1GFSDUB-SFa65y_0HsxlhfUjtrdb51X6uc_Xpqi3r8wHrOOVsWHre7TCoMl49JJWth2Bh7RPYotbR_6fIO5fRmlw</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Nakanishi, Kuniaki</creator><creator>Kawai, Toshiaki</creator><creator>Torikata, Chikao</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>Immunohistochemical evaluation of p53 oncoprotein in transitional cell carcinoma of the upper urinary tract</title><author>Nakanishi, Kuniaki ; Kawai, Toshiaki ; Torikata, Chikao</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c484t-64b2eb56561760f869bee273b15bbf44cffe3bb80f53ac5a3009e567b42451653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Carcinoma, Transitional Cell - chemistry</topic><topic>Carcinoma, Transitional Cell - mortality</topic><topic>Carcinoma, Transitional Cell - pathology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Nephrology. Urinary tract diseases</topic><topic>p53 oncoprotein</topic><topic>Prognosis</topic><topic>Survival Rate</topic><topic>transitional cell carcinoma</topic><topic>Tumor Suppressor Protein p53 - biosynthesis</topic><topic>Tumor Suppressor Protein p53 - immunology</topic><topic>Tumors of the urinary system</topic><topic>upper urinary tract</topic><topic>Urinary tract. Prostate gland</topic><topic>Urologic Neoplasms - chemistry</topic><topic>Urologic Neoplasms - mortality</topic><topic>Urologic Neoplasms - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Nakanishi, Kuniaki</creatorcontrib><creatorcontrib>Kawai, Toshiaki</creatorcontrib><creatorcontrib>Torikata, Chikao</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Human pathology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Nakanishi, Kuniaki</au><au>Kawai, Toshiaki</au><au>Torikata, Chikao</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunohistochemical evaluation of p53 oncoprotein in transitional cell carcinoma of the upper urinary tract</atitle><jtitle>Human pathology</jtitle><addtitle>Hum Pathol</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>27</volume><issue>12</issue><spage>1336</spage><epage>1340</epage><pages>1336-1340</pages><issn>0046-8177</issn><eissn>1532-8392</eissn><coden>HPCQA4</coden><abstract>The p53 gene, which is located on human chromosome 17, encodes for a nuclear phosphoprotein and is thought to regulate cell growth and proliferation. Although the immunoreactivity for p53 oncoprotein in transitional cell carcinoma (TCC) of the urinary bladder has been shown to correlate with clinicopathologic findings and prognoses, there have been no such reports on TCC of the upper urinary tract (TCC-UUT). The present study investigated the prognostic value of p53 oncoprotein in TCC-UUT. Formalin-fixed, paraffin-embedded tumor tissues from 149 TCC-UUT patients were analyzed using immunohistochemical staining. Immunohistochemically, p53 oncoprotein was recognized as positive in 26.8% of the samples. The immunoreactivity for p53 oncoprotein was significantly (
P < .05) correlated with both stage, grade, and pattern of growth. The 5-year disease-free and overall survival rates were 58.4% and 69.7%, respectively. A univariate analysis of survival showed that stage, grade, pattern of growth, and the immunoreactivity for p53 oncoprotein have a significant effect on disease-free and overall survival rates. In the final models of multivariate analysis, only stage for disease-free survival, and stage and the immunoreactivity for p53 oncoprotein for overall survival were found to be progressive or prognostic factors. Detection of immunoreactivity for p53 oncoprotein appears to be of real value in deciding the prognosis of TCC-UUT.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8958308</pmid><doi>10.1016/S0046-8177(96)90347-0</doi><tpages>5</tpages></addata></record> |
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subjects | Aged Biological and medical sciences Carcinoma, Transitional Cell - chemistry Carcinoma, Transitional Cell - mortality Carcinoma, Transitional Cell - pathology Female Humans Immunohistochemistry Male Medical sciences Middle Aged Multivariate Analysis Nephrology. Urinary tract diseases p53 oncoprotein Prognosis Survival Rate transitional cell carcinoma Tumor Suppressor Protein p53 - biosynthesis Tumor Suppressor Protein p53 - immunology Tumors of the urinary system upper urinary tract Urinary tract. Prostate gland Urologic Neoplasms - chemistry Urologic Neoplasms - mortality Urologic Neoplasms - pathology |
title | Immunohistochemical evaluation of p53 oncoprotein in transitional cell carcinoma of the upper urinary tract |
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