HIV protease and the pathogenesis of AIDS

The pathogenesis of the acquired immunodeficiency syndrome (AIDS) involves persistent interaction between the human immunodeficiency virus (HIV) and the host immune system. Although antiretroviral agents are presumed to disrupt this interaction by inhibiting viral replication, it has been hypothesiz...

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Bibliographic Details
Published in:Research in virology (Paris) 1996-11, Vol.147 (6), p.375-379
Main Authors: GOLDBERG, B, STRICKER, R. B
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - immunology
Acquired Immunodeficiency Syndrome - virology
AIDS/HIV
Animals
Anti-HIV Agents - pharmacology
Biological and medical sciences
Fundamental and applied biological sciences. Psychology
HIV Protease - physiology
HIV Protease Inhibitors - pharmacology
human immunodeficiency virus
Humans
Microbiology
Proteins - metabolism
Replicative cycle, interference, host-virus relations, pathogenicity, miscellaneous strains
Virology
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Summary:The pathogenesis of the acquired immunodeficiency syndrome (AIDS) involves persistent interaction between the human immunodeficiency virus (HIV) and the host immune system. Although antiretroviral agents are presumed to disrupt this interaction by inhibiting viral replication, it has been hypothesized that nucleoside analogs such as zidovudine (AZT) may also have a direct effect on the human cellular immune response (Levy et al., 1996). This concept of antiretroviral agents directly promoting host cell function has been termed the "host response" hypothesis, and support for this concept has previously been published (Dadaglio et al., 1992). Drawing on biochemical and immunologic studies, we have applied this hypothesis to another aspect of HIV disease: HIV protease and the protease inhibitors. The resultant novel concept of AIDS pathogenesis is outlined below.
ISSN:0923-2516
DOI:10.1016/S0923-2516(97)85129-1