Expanded CAG/CTG repeats in schizophrenia. A study of clinical correlates

Schizophrenia is associated with expanded CAG/CTG trinucleotide repeats. We wished to determine whether the presence of such expansions correlated with specific subsyndromes or other clinical features of schizophrenia. Seventy patients from England and Wales and 44 patients from Portugal with a DSM-...

Full description

Saved in:
Bibliographic Details
Published in:British journal of psychiatry 1996-12, Vol.169 (6), p.766-771
Main Authors: Cardno, AG, Murphy, KC, Jones, LA, Guy, CA, Asherson, P, De Azevedo, MH, Coelho, IM, de Macedo e Santos, AJ, Pato, CN, McGuffin, P, Owen, MJ, O'Donovan, MC
Format: Article
Language:English
Subjects:
Adult
Cross-Cultural Comparison
England
Female
Humans
Male
Medical diagnosis
Mental disorders
Middle Aged
Phenotype
Phenotypes
Polyglutamine
Portugal
Psychiatric Status Rating Scales
Schizophrenia
Schizophrenia - classification
Schizophrenia - diagnosis
Schizophrenia - genetics
Syndrome
Trinucleotide repeats
Trinucleotide Repeats - genetics
Wales
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Schizophrenia is associated with expanded CAG/CTG trinucleotide repeats. We wished to determine whether the presence of such expansions correlated with specific subsyndromes or other clinical features of schizophrenia. Seventy patients from England and Wales and 44 patients from Portugal with a DSM-III-R diagnosis of schizophrenia were rated on the OPCRIT checklist. Patient's maximum CAG/CTG repeat length was measured using repeat expansion detection (RED). Significant differences were sought for repeat lengths in subjects categorised according to dimensional and categorical schizophrenia subsyndromes, affective episodes, individual symptoms, and a range of demographic variables. Maximum CAG/CTG repeat length did not differ significantly for any of the clinical or demographic variables studied. There are no subsyndromes or other clinical features of schizophrenia associated with CAG/CTG repeat expansion. Therefore, the identification of the gene(s) that contain expanded CAG/CTG repeats and which are associated with schizophrenia is unlikely to be facilitated at present by using any subsyndromes of schizophrenia as phenotypes.
ISSN:0007-1250
1472-1465
DOI:10.1192/bjp.169.6.766