Subacute sclerosing panencephalitis

Subacute sclerosing panencephalitis (SSPE), a neurodegenerative disease caused by a persistent “slow virus infection” with a mutated measles virus, is endemic in much of the developing world. Its incidence will increase in the USA, not only in immigrants, but also because of the 1988–1990 measles ep...

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Bibliographic Details
Published in:Seminars in pediatric neurology 1996-12, Vol.3 (4), p.260-269
Main Author: Gascon, Generoso G.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brain - pathology
Child
Child, Preschool
Defective Viruses - genetics
Humans
Infant
Interferon-alpha - administration & dosage
Measles virus - genetics
Mutation - genetics
Neurologic Examination - drug effects
SSPE Virus - genetics
Subacute Sclerosing Panencephalitis - diagnosis
Subacute Sclerosing Panencephalitis - therapy
Subacute Sclerosing Panencephalitis - virology
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Summary:Subacute sclerosing panencephalitis (SSPE), a neurodegenerative disease caused by a persistent “slow virus infection” with a mutated measles virus, is endemic in much of the developing world. Its incidence will increase in the USA, not only in immigrants, but also because of the 1988–1990 measles epidemic. This report reviews the pathogenesis, clinical and laboratory diagnosis, and future perspectives in treatment and prevention.
ISSN:1071-9091
1558-0776
DOI:10.1016/S1071-9091(96)80030-1