A rat model of infection by Salmonella typhimurium or Salm. enteritidis

Salmonellosis in the rat has many similarities with the disease in humans, with the ileum thought to be the main site of colonization/invasion in both species. Thus, the rat may be a useful way to study the mechanism of infection by these pathogenic bacteria. A series of infection trials carried out...

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Bibliographic Details
Published in:Journal of Applied Bacteriology 1996-12, Vol.81 (6), p.651-656
Main Authors: Naughton, P.J., Grant, G., Spencer, R.J., Bardocz, S., Pusztai, A.
Format: Article
Language:English
Subjects:
Animals
Bacteriological Techniques
Bacteriology
Biological and medical sciences
Disease Models, Animal
Fundamental and applied biological sciences. Psychology
Ileum - microbiology
Jejunum - microbiology
Microbiology
Organ Size
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Rats
Rats, Inbred Strains
Salmonella enteritidis
Salmonella Infections, Animal
Salmonella typhimurium
Specific Pathogen-Free Organisms
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Summary:Salmonellosis in the rat has many similarities with the disease in humans, with the ileum thought to be the main site of colonization/invasion in both species. Thus, the rat may be a useful way to study the mechanism of infection by these pathogenic bacteria. A series of infection trials carried out with Hooded Lister rats showed that a salmonella infection persisted for an extended period of time and that salmonellae bind to the small intestinal epithelium as early as 4 h after intragastric intubation. Reinfection from the large intestine may not therefore initially play a significant role in the salmonella infection process. The rat model may therefore provide a means to test in vivo interventionist strategies, designed to block binding of the pathogens in the gastrointestinal tract.
ISSN:0021-8847
2056-5232
DOI:10.1111/j.1365-2672.1996.tb03560.x