Enhancement of phagocytosis by calcitonin gene-related peptide (CGRP) in cultured mouse peritoneal macrophages

Calcitonin gene-related peptide (CGRP) is widely distributed in sensory neurons and nerve fibers. To clarify the function of CGRP on the immune system, the effect of CGRP on phagocytosis by peritoneal mactophages was examined by means of flow cytofluorometry. CGRP enhanced phagocytosis of latex bead...

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Bibliographic Details
Published in:Peptides (New York, N.Y. : 1980) N.Y. : 1980), 1996, Vol.17 (8), p.1405-1414
Main Authors: Ichinose, Mitsuyuki, Sawada, Masashi
Format: Article
Language:English
Subjects:
1-Methyl-3-isobutylxanthine - pharmacology
Amino Acid Sequence
Amyloid - genetics
Amyloid - pharmacology
Animals
Calcitonin - genetics
Calcitonin - pharmacology
Calcitonin gene-related peptide (CGRP)
Calcitonin Gene-Related Peptide - genetics
Calcitonin Gene-Related Peptide - pharmacology
Calcitonin Gene-Related Peptide - physiology
Cells, Cultured
Cyclic AMP - metabolism
Flow cytofluorometry
Glucans
Humans
Islet Amyloid Polypeptide
Lectins, C-Type
Macrophages
Macrophages, Peritoneal - drug effects
Macrophages, Peritoneal - immunology
Macrophages, Peritoneal - physiology
Mannose - pharmacology
Mannose-Binding Lectins
Mice
Molecular Sequence Data
Peptide Fragments - pharmacology
Phagocytosis
Phagocytosis - drug effects
Phagocytosis - physiology
Phosphodiesterase Inhibitors - pharmacology
Polysaccharides - pharmacology
Rats
Receptors, Cell Surface - drug effects
Receptors, Cell Surface - physiology
Receptors, Mitogen - drug effects
Receptors, Mitogen - physiology
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Summary:Calcitonin gene-related peptide (CGRP) is widely distributed in sensory neurons and nerve fibers. To clarify the function of CGRP on the immune system, the effect of CGRP on phagocytosis by peritoneal mactophages was examined by means of flow cytofluorometry. CGRP enhanced phagocytosis of latex beads in a dose-dependent manner. Because the phosphodiesterase inhibitor 3-isobutyl-1-methylxanthine (IBMX) enhanced the CGRP-induced enhancement of phagocytosis, the enhancement might be mediated by cAMP. In the presence of mannan, the phagocytosis was suppressed and the CGRP-induced enhancement was also blocked, suggesting that mannose receptors on macrophages were involved in mediating the phagocytosis of latex beads, and CGRP enhanced the mannose receptor-mediated phagocytosis. The present results indicate that CGRP can modulate the function of macrophages in nerve terminals of sensory neurons during the development and maintenance of inflammation.
ISSN:0196-9781
1873-5169
DOI:10.1016/S0196-9781(96)00198-2