Mouse model for evaluation of antibiotic treatment of acute and chronic infections

A thread model is presented which enables the simultaneous evaluation of bactericidal rate and antibiotic concentration at the site of infection in mice. Ampicillin and netilmicin were tested against both gram-positive and gram-negative bacteria. With the doses tested there was substantial drug pene...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 1988-12, Vol.7 (6), p.753-757
Main Authors: Renneberg, J, Walder, M
Format: Article
Language:English
Subjects:
Acute Disease
Animals
Anti-Bacterial Agents - pharmacokinetics
Anti-Bacterial Agents - therapeutic use
Bacterial Infections - drug therapy
Chronic Disease
Disease Models, Animal
Female
Mice
Mice, Inbred BALB C
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:A thread model is presented which enables the simultaneous evaluation of bactericidal rate and antibiotic concentration at the site of infection in mice. Ampicillin and netilmicin were tested against both gram-positive and gram-negative bacteria. With the doses tested there was substantial drug penetration into the site of infection immediately after initiation of infection (day 0), whereas the drug penetration on days 2 and 6 of infection was delayed and reduced. On day 0 of infection there was significant bactericidal effect, but little or no effect could be demonstrated on days 2 and 6 of infection, even though drug concentrations close to the MBC values for several drug/bacteria combinations were reached. The model reflects the treatment situations for the acute and the chronic infection and may be of help in evaluating the efficacy of the drug at the site of infection.
ISSN:0934-9723
1435-4373
DOI:10.1007/BF01975042