Synthesis and preliminary evaluation of (S)-(2-[ 18F]fluoro-4,5-dihydroxyphenyl)-2-methyl l-alanine, (S)-[ 18F]-FMEDOPA, a potentially improved imaging agent for the presynaptic dopaminergic nervous system

The synthesis and preliminary rat biodistribution studies of (S)-(2-[ 18F]fluoro-4,5-dihydroxyphenyl)-2-methyl l-alanine, (S)-[ 18F]-FMEDOPA, a potentially improved imaging agent for the presynaptic dopaminergic nervous system, are reported. (S)-[ 18F]-FMEDOPA produces a higher striatumto-cerebellum...

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Bibliographic Details
Published in:Nuclear medicine and biology 1996-10, Vol.23 (7), p.857-865
Main Authors: Yost, Yul, Conway, Terry
Format: Article
Language:English
Subjects:
2-[ 18F]fluoro-4
5-dihydroxyphenyl)-2-methyl l-alanine
[ 18F]-FDOPA
[ 18F]-FMEDOPA
Animals
Biological and medical sciences
Cerebellum - diagnostic imaging
Cerebellum - metabolism
Corpus Striatum - diagnostic imaging
Corpus Striatum - metabolism
Dihydroxyphenylalanine - analogs & derivatives
Dihydroxyphenylalanine - chemical synthesis
Dihydroxyphenylalanine - chemistry
Dihydroxyphenylalanine - pharmacokinetics
Dopamine - metabolism
dopaminergic nervous system
Fluorine Radioisotopes - pharmacokinetics
Indicators and Reagents
Investigative techniques, diagnostic techniques (general aspects)
Magnetic Resonance Spectroscopy
Medical sciences
Miscellaneous. Technology
Molecular Structure
PET imaging agent
Radionuclide investigations
Rats
Time Factors
Tissue Distribution
Tomography, Emission-Computed
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Summary:The synthesis and preliminary rat biodistribution studies of (S)-(2-[ 18F]fluoro-4,5-dihydroxyphenyl)-2-methyl l-alanine, (S)-[ 18F]-FMEDOPA, a potentially improved imaging agent for the presynaptic dopaminergic nervous system, are reported. (S)-[ 18F]-FMEDOPA produces a higher striatumto-cerebellum ( S C ) radioactivity ratio than the currently used PET imaging agent, (S)-[ 18F]-FDOPA, does at 180 min after administration.
ISSN:0969-8051
1872-9614
DOI:10.1016/S0969-8051(96)00056-X