Clinical Evaluation of Global Change in Alzheimer's Disease: Identifying Consensus

It is important that clinicians who rate global change as part of Alzheimer's disease (AD) clinical drug trials agree on a relevant set of behaviors and information to be considered in formulating their rating. Yet, consensus among raters has been difficult to establish, and inter-rater reliabi...

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Bibliographic Details
Published in:Journal of geriatric psychiatry and neurology 1996-10, Vol.9 (4), p.176-180
Main Authors: Olin, Jason T., Schneider, Lon S., Doody, Rachelle S., Clark, Christopher M., Ferris, Steven H., Morris, John C., Reisberg, Barry, Schmitt, Frederick A.
Format: Article
Language:English
Subjects:
Alzheimer Disease - psychology
Biological and medical sciences
Decision Making
Geriatrics
Humans
Medical sciences
Psychiatric Status Rating Scales
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Surveys and Questionnaires
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Summary:It is important that clinicians who rate global change as part of Alzheimer's disease (AD) clinical drug trials agree on a relevant set of behaviors and information to be considered in formulating their rating. Yet, consensus among raters has been difficult to establish, and inter-rater reliability of clinical global impression of change (CGIC) ratings has been low. In preparation for the development of a new CGIC scale to be used in AD clinical trials, the Alzheimer's Disease Cooperative Study-Clinical Global Impression of Change (ADCS-CGIC), we surveyed clinicians at sites comprising the National Institute on Aging-sponsored ADCS participating centers to identify whether or not consensus regarding CGICs exists. Overall, respondents reported that a CGIC should include an assessment of the patient's function and mental status, a care giver interview, and a standardized set of questions, and it should take approximately 20 minutes per interview. Depending on a patient's level of impairment, raters consider different areas of behavior in formulating a CGIC rating. These findings demonstrate the considerable consensus regarding the CGIC rating process, and were integrated into the design of the ADCS-CGIC, currently in use.
ISSN:0891-9887
1552-5708
DOI:10.1177/089198879600900404