Positive chronotropic effects of endothelin, a novel endothelium-derived vasoconstrictor peptide

Endothelin (ET) is a novel 21-amino-acid peptide isolated from the culture supernatant of porcine aortic endothelial cells, which has a potent vasoconstricting effect. It has been suggested that ET increases Ca2+ influx via a voltage-dependent Ca2+ channel. The purpose of the present study is to inv...

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Bibliographic Details
Published in:Pflügers Archiv 1988-11, Vol.413 (1), p.108-110
Main Authors: ISHIKAWA, T, YANAGISAWA, M, KIMURA, S, GOTO, K, MASAKI, T
Format: Article
Language:English
Subjects:
3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester - pharmacology
Animals
Biological and medical sciences
Endothelins
Endothelium, Vascular - cytology
Fundamental and applied biological sciences. Psychology
Guinea Pigs
Heart
Heart Rate - drug effects
In Vitro Techniques
Male
Myocardial Contraction - drug effects
Peptides - pharmacology
Vasoconstrictor Agents - pharmacology
Vertebrates: cardiovascular system
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Summary:Endothelin (ET) is a novel 21-amino-acid peptide isolated from the culture supernatant of porcine aortic endothelial cells, which has a potent vasoconstricting effect. It has been suggested that ET increases Ca2+ influx via a voltage-dependent Ca2+ channel. The purpose of the present study is to investigate the mode of actions of ET on the cardiac automaticity. ET increased the sinoatrial nodal rate in a dose-dependent manner on the isolated right atria of guinea pigs. The positive chronotropic effect of ET was very potent and the ED50 value was 0.4 nM. These results suggest that ET is one of the most potent cardio-acceleratory substances.
ISSN:0031-6768
1432-2013
DOI:10.1007/bf00581239