The Acer gene of Drosophila codes for an angiotensin-converting enzyme homologue

Mammalian angiotensin-converting enzyme (ACE) exists as two forms, somatic (sACE), controlling blood pressure via angiotensin II, and testicular (tACE), whose function is unknown. The former has two highly homologous N- and C-terminal Zn 2+ metallopeptidase active sites, whereas the latter only has...

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Bibliographic Details
Published in:Gene 1996-11, Vol.181 (1), p.191-197
Main Authors: Taylor, Christine A.M., Coates, David, Shirras, Alan D.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
amino acid sequences
Animals
Base Sequence
Blotting, Northern
Cloning, Molecular
complementary DNA
Dipeptidyl dipeptidase
Dna sequencing
DNA, Complementary
Drosophila - genetics
Drosophila - metabolism
Drosophila melanogaster
Drosophila Proteins
embryo (animal)
embryogenesis
Female
genbank/x96913
Gene duplication
gene expression
Heart
Humans
In Situ Hybridization
Insect Proteins - classification
Insect Proteins - genetics
Larva - metabolism
Male
messenger RNA
Metalloendopeptidases - classification
Metalloendopeptidases - genetics
Metalloproteinase
Molecular Sequence Data
nucleotide sequences
peptidases
Peptidyl-Dipeptidase A - classification
Peptidyl-Dipeptidase A - genetics
Phylogeny
RNA, Messenger - analysis
Sequence Homology, Amino Acid
structural genes
Zn 2+-Binding motif
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Summary:Mammalian angiotensin-converting enzyme (ACE) exists as two forms, somatic (sACE), controlling blood pressure via angiotensin II, and testicular (tACE), whose function is unknown. The former has two highly homologous N- and C-terminal Zn 2+ metallopeptidase active sites, whereas the latter only has one, which is identical to the C-terminal domain of sACE. We have sequenced 2452 bases of a 3.1-kb mRNA whose predicted translation product shows 40% identity with mammalian testicular ACE, and 48% identity with an already identified Drosophila homologue of ACE (Ance). We have termed this gene Acer (Angiotensin converting enzyme-related). Acer mRNA is found in the developing dorsal vessel (heart) during embryogenesis. Phylogenetic analysis indicates that duplication of an ancestral ACE gene occurred in the lineage leading to the arthropods, independently of the duplication which gave rise to the two domain somatic ACE of mammals.
ISSN:0378-1119
1879-0038
DOI:10.1016/S0378-1119(96)00503-3