X-MyT1, a Xenopus C2HC-Type Zinc Finger Protein with a Regulatory Function in Neuronal Differentiation

X-MyT1 is a C2HC-type zinc finger protein that we find to be involved in the primary selection of neuronal precursor cells in Xenopus. Expression of this gene is positively regulated by the bHLH protein X-NGNR-1 and negatively regulated by the Notch/Delta signal transduction pathway. X-MyT1 is able...

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Bibliographic Details
Published in:Cell 1996-12, Vol.87 (7), p.1191-1202
Main Authors: Bellefroid, Eric J, Bourguignon, Catherine, Hollemann, Thomas, Ma, Qiufu, Anderson, David J, Kintner, Chris, Pieler, Tomas
Format: Article
Language:English
Subjects:
Age Factors
Amino Acid Sequence
Animals
Basic Helix-Loop-Helix Transcription Factors
Cell Differentiation
DNA-Binding Proteins - physiology
Embryonic Induction
Freshwater
Gene Expression Regulation, Developmental
Helix-Loop-Helix Motifs
In Situ Hybridization
Molecular Sequence Data
Nerve Tissue Proteins
Nervous System - embryology
Neurons - cytology
Neuropeptides - genetics
Trans-Activators
Transcription Factors - physiology
Tubulin - genetics
Xenopus
Xenopus laevis
Xenopus Proteins
Zinc Fingers
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Summary:X-MyT1 is a C2HC-type zinc finger protein that we find to be involved in the primary selection of neuronal precursor cells in Xenopus. Expression of this gene is positively regulated by the bHLH protein X-NGNR-1 and negatively regulated by the Notch/Delta signal transduction pathway. X-MyT1 is able to promote ectopic neuronal differentiation and to confer insensitivity to lateral inhibition, but only in cooperation with bHLH transcription factors. Inhibition of X-MyT1 function inhibits normal neurogenesis as well as ectopic neurogenesis caused by overexpression of X-NGNR-1. On the basis of these findings, we suggest that X-MyT1 is a novel, essential element in the cascade of events that allows cells to escape lateral inhibition and to enter the pathway that leads to terminal neuronal differentiation.
ISSN:0092-8674
1097-4172
DOI:10.1016/S0092-8674(00)81815-2