Brain pH in Migraine: An In Vivo Phosphorus-31 Magnetic Resonance Spectroscopy Study

The intracellular pH (pHi) of cerebral cortex was measured in migraine patients by use of in vivo phosphorus-31 NMR spectroscopy. No changes in pHi were measured during a migraine attack. The long-standing concept that the headache of migraine is due to cerebral vaso-dilatation induced by prodromal...

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Bibliographic Details
Published in:Cephalalgia 1988-12, Vol.8 (4), p.273-277
Main Authors: Welch, K M A, Levine, Steven R, D'Andrea, Giovanni, Helpern, J A
Format: Article
Language:English
Subjects:
Adult
Brain - metabolism
Female
Humans
Hydrogen-Ion Concentration
Magnetic Resonance Spectroscopy
Middle Aged
migraine
Migraine Disorders - metabolism
phosphorus‐31
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Summary:The intracellular pH (pHi) of cerebral cortex was measured in migraine patients by use of in vivo phosphorus-31 NMR spectroscopy. No changes in pHi were measured during a migraine attack. The long-standing concept that the headache of migraine is due to cerebral vaso-dilatation induced by prodromal vasospasm-induced ischemic acidosis is not substantiated.
ISSN:0333-1024
1468-2982
DOI:10.1046/j.1468-2982.1988.0804273.x