Elution characteristics of vancomycin and tobramycin combined in acrylic bone—cement

Combining two antibiotics in antibiotic-loaded bone-cement is common in clinical practice. As the effect this has on elution characteristics is unknown, an in vivo quantitative elution study was carried out. Three groups of five antibiotic-loaded cement disks were prepared and placed in individual s...

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Bibliographic Details
Published in:The Journal of arthroplasty 1996-12, Vol.11 (8), p.939-944
Main Authors: Penner, Murray J., Masri, Basam A., Duncan, Clive P.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - administration & dosage
antibiotic
Bone Cements
bone—cement
Drug Carriers
Drug Delivery Systems
Drug Therapy, Combination - administration & dosage
elution
Methylmethacrylates
tobramycin
Tobramycin - administration & dosage
vancomycin
Vancomycin - administration & dosage
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Summary:Combining two antibiotics in antibiotic-loaded bone-cement is common in clinical practice. As the effect this has on elution characteristics is unknown, an in vivo quantitative elution study was carried out. Three groups of five antibiotic-loaded cement disks were prepared and placed in individual saline baths for 5 weeks. The elution of tobramycin from the disks in the study group (containing 2.4 g tobramycin and 1.0 g vancomycin per 40-g packet of Palacos-R cement powder [Smith & Nephew Orthopaedics, Memphis, TN]) was increased by 68% over that of the tobramycin control disks (2.4 g tobramycin only) ( P = .024). The release of vancomycin from the study group disks was increased by 103% over the vancomycin control disks (1.0 g vancomycin only) ( P = .007). Combining two antibiotics in bone—cement improves elution of both antibiotics in vitro and may translate into enhanced elution in vivo.
ISSN:0883-5403
1532-8406
DOI:10.1016/S0883-5403(96)80135-5