Fusaricide, a New Cytotoxic N-Hydroxypyridone from Fusarium sp

• Published in: Journal of natural products (Washington, D.C.) D.C.), 1996-12, Vol.59 (12), p.1151-1153
• Main Authors: McBrien, Kimberly D, Gao, Qi, Huang, Stella, Klohr, Steven E, Wang, Richard R, Pirnik, Dolores M, Neddermann, Kim M, Bursuker, Isia, Kadow, Kathleen F, Leet, John E
• Format: Article
• Language: English
• Subjects: Antibiotics, microbial producers, chemotherapic agents, antiseptics, disinfecting agents; Antifungal Agents - pharmacology; Antineoplastic Agents - isolation & purification; Antineoplastic Agents - pharmacology; ANTIVIRAL; ANTIVIRAL AGENTS; Applied microbiology; Benzopyrans - isolation & purification; Benzopyrans - pharmacology; Biological and medical sciences; CHEMICAL COMPOSITION; CHEMICAL STRUCTURE; Chemotherapic agents; COMPOSICION QUIMICA; COMPOSITION CHIMIQUE; Crystallography, X-Ray; CYTOTOXIC COMPOUNDS; DRUG PLANTS; ESPECTROMETRIA; ESTRUCTURA QUIMICA; Fundamental and applied biological sciences. Psychology; Fungi - drug effects; FUSARIUM; Fusarium - chemistry; Gene Expression Regulation, Viral - drug effects; GENERO HUMANO; GENRE HUMAIN; GEORGIA (EUA); GEORGIA (USA); GEORGIE (EU); HERPETOVIRIDAE; HUMAN IMMUNODEFICIENCY VIRUS; MANKIND; MICOTOXINAS; Microbial Sensitivity Tests; Microbiology; MYCOTOXINE; MYCOTOXINS; PLANTAS MEDICINALES; PLANTE MEDICINALE; Pyridones - isolation & purification; Pyridones - pharmacology; SPECTRAL ANALYSIS; SPECTROMETRIE; SPECTROMETRY; STRUCTURE CHIMIQUE; SUBSTANCE TOXIQUE; SUSTANCIAS TOXICAS; TOXIC SUBSTANCES; Tumor Cells, Cultured; VIRICIDAS; Virion - drug effects
• ISSN: 0163-3864; 1520-6025
• DOI: 10.1021/np960521t

A new cytotoxic N-hydroxypyridone, fusaricide (1), was isolated from a Fusarium sp. Its structure was solved by X-ray diffraction and spectroscopic analyses.