Enhanced Gastrointestinal Absorption of Aluminium in Uraemia: Time Course and Effect of Vitamin D

• Published in: Nephrology, dialysis, transplantation dialysis, transplantation, 1988, Vol.3 (5), p.617-623
• Main Authors: Ittel, T.H., Kluge, R., Sieberth, H.G.
• Format: Article
• Language: English
• Subjects: 25(OH)2D3; Administration, Oral; Aluminium; Aluminum - metabolism; Aluminum - pharmacokinetics; Aluminum Chloride; Aluminum Compounds; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Animals; Biological and medical sciences; Calcifediol - blood; Calcitriol - administration & dosage; Calcitriol - pharmacology; Chlorides - metabolism; Chlorides - pharmacokinetics; Emergency and intensive care: renal failure. Dialysis management; Gastrointestinal absorption; Injections, Intravenous; Injections, Subcutaneous; Intensive care medicine; Intestinal Absorption - drug effects; Male; Medical sciences; Metabolic Clearance Rate - drug effects; Nephrectomy; Rats; Rats, Inbred Strains; Uraemia; Uremia - metabolism; Vitamin D; Vitamin D Deficiency - metabolism
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/oxfordjournals.ndt.a091716

The present study examines the time course of aluminium absorption in uraemic rats vs controls and investigates the effect of vitamin D. Following an oral load of 410 μmol aluminium there was a significant increase in the urinary excretion rate of aluminium as early as 60 min in uraemic rats. Compared with controls this increase was significantly greater in uraemic animals and maximum excretion rates (77±49 vs pre-load 2±1 nmol Al/h) were achieved after 2 h. When vitamin-D-deficient rats with normal renal function were compared with vitamin-D-replete controls, the latter excreted a significantly greater amount of the oral dose of aluminium in their urine (727±361 vs 359±l40nmol Al/5d; P