Class II (DR) antigen expression on CD8+ lymphocyte subsets in acquired immune deficiency syndrome (AIDS)

In a selected group of human immunodeficiency virus (HIV)-infected patients we confirm the expansion of a CD8+ T-lymphocyte subset, i.e., the CD8+/Leu7+ cells, which account for 30% of the lymphocytes, compared to 3% in the control donors. In addition, a CD8+ T-lymphocyte subset that coexpresses cla...

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Bibliographic Details
Published in:Journal of clinical immunology 1988-11, Vol.8 (6), p.473-478
Main Authors: ZIEGLER-HEITBROCK, H. W. L, STACHEL, D, SCHLUNK, T, GÜRTLER, L, SCHRAMM, W, FRÖSCHL, M, BOGNER, J. R, RIETHMÜLLER, G
Format: Article
Language:English
Subjects:
Acquired Immunodeficiency Syndrome - immunology
Adult
AIDS-Related Complex - immunology
AIDS/HIV
Antigens, Differentiation, T-Lymphocyte - analysis
Biological and medical sciences
Flow Cytometry
Hemophilia A - immunology
HLA-DR Antigens - analysis
Homosexuality
Humans
Immunodeficiencies
Immunodeficiencies. Immunoglobulinopathies
Immunopathology
Male
Medical sciences
T-Lymphocytes, Regulatory - classification
T-Lymphocytes, Regulatory - immunology
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Summary:In a selected group of human immunodeficiency virus (HIV)-infected patients we confirm the expansion of a CD8+ T-lymphocyte subset, i.e., the CD8+/Leu7+ cells, which account for 30% of the lymphocytes, compared to 3% in the control donors. In addition, a CD8+ T-lymphocyte subset that coexpresses class II (DR) antigens, i.e., CD8+/DR+ cells, is also increased from 1.5% in controls to 27% in the HIV-infected patients. Using three-color immunofluorescence and flow cytometry we can demonstrate that the CD8+/Leu7+ and the CD8+/class II+ cells are not distinct but overlapping subsets. In the HIV-infected patients 42% of the CD8+/Leu7+ cells were strongly positive for class II and these CD8+/Leu7+/class II+ cells accounted for 13% of all lymphocytes. These findings indicate that the expanded CD8+/Leu7+ cells are activated and hence might be actively involved in immune defense in acquired immune deficiency syndrome (AIDS).
ISSN:0271-9142
1573-2592
DOI:10.1007/BF00916953