First trimester bleeding in clinical IVF pregnancies

First trimester bleeding has been investigated in 72 pregnant women undergoing in-vitro fertilization and embryo transfer and was compared to 70 pregnant patients in whom ovula tion was induced, in addition to 70 spontaneous pregnancies. Abortion rates did not differ significantly between the first...

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Bibliographic Details
Published in:Human reproduction (Oxford) 1988-08, Vol.3 (6), p.807-809
Main Authors: Goldman, Jack A., Ashkenazi, Jack, Ben-David, Mordechai, Feldberg, Dov, Dicker, Dov, Voliovitz, Issachar
Format: Article
Language:English
Subjects:
17 alpha-Hydroxyprogesterone Caproate
Chorionic Gonadotropin - blood
Delayed-Action Preparations
Embryo Transfer
Female
Fertilization in Vitro
first trimester bleeding
Humans
Hydroxyprogesterones - therapeutic use
IVF pregnancy
Pregnancy
Pregnancy Complications, Hematologic - drug therapy
Pregnancy Complications, Hematologic - physiopathology
Pregnancy Trimester, First
Progesterone - blood
Progesterone Congeners - therapeutic use
Risk Factors
Uterine Hemorrhage - physiopathology
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Summary:First trimester bleeding has been investigated in 72 pregnant women undergoing in-vitro fertilization and embryo transfer and was compared to 70 pregnant patients in whom ovula tion was induced, in addition to 70 spontaneous pregnancies. Abortion rates did not differ significantly between the first two groups but were significantly higher in comparison to normal pregnancies. Furthermore, among IVF pregnancies that continued, a high incidence of first trimester bleeding occurred (P < 0.01). This complication was mainly related to luteal insufficiency and multiple pregnancies, whereas hyperstimulation was the major risk factor for bleeding in pregnancies arising from HMG-induced ovulation. Other currently unknown, aetiological factors for first trimester bleeding in IVF pregnancies remain to be investigated.
ISSN:0268-1161
1460-2350
DOI:10.1093/oxfordjournals.humrep.a136787