Immunoglobulin G in multiple sclerosis brain

We extracted free and bound IgG from plaques and normal-appearing white matter of multiple sclerosis (MS) brains. By isoelectric focusing (IEF), three patterns of IgG distribution were seen: (A) a restricted high-pI distribution with a specific band at low pH, (B) a restricted high-pI pattern, and (...

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Bibliographic Details
Published in:Metabolic brain disease 1988-09, Vol.3 (3), p.179-184
Main Authors: HOSOKAWA, T, HUNT, J. C, MARCHALONIS, J. J, HOGAN, E. L
Format: Article
Language:English
Subjects:
Biological and medical sciences
Brain - immunology
Humans
Hydrogen-Ion Concentration
Immunoenzyme Techniques
Immunoglobulin G - analysis
Isoelectric Focusing
Medical sciences
Multiple Sclerosis - immunology
Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis
Neurology
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Summary:We extracted free and bound IgG from plaques and normal-appearing white matter of multiple sclerosis (MS) brains. By isoelectric focusing (IEF), three patterns of IgG distribution were seen: (A) a restricted high-pI distribution with a specific band at low pH, (B) a restricted high-pI pattern, and (C) a broad pI pattern similar to that of the unbound IgG extracted at neutral pH. In one MS brain, we compared the IEF pattern of plaque material with that of normal-appearing white matter (NAWM); the low-pH extract of plaque material (PM) had a restricted pattern at high pI. In another MS brain, a specific band of bound IgG was found. These data suggest that MS lesions expose an antigen(s) unique to MS. B cells consequently might be stimulated by a disease-related antigen(s) in the MS lesion.
ISSN:0885-7490
1573-7365
DOI:10.1007/BF00999234