Intraventricular injections of galanin reduces 5-HT metabolism in the ventral limbic cortex, the hippocampal formation and the fronto-parietal cortex of the male rat

To understand the role of galanin in the 5-hydroxytryptamine (5-HT) neurons the authors have investigated possible galanin/5-HT interactions at the presynaptic level by analysing the effects of intraventricular injections of galanin on 5-HT levels and metabolism in various cortical regions of the ma...

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Bibliographic Details
Published in:Acta physiologica Scandinavica 1988-08, Vol.133 (4), p.579-581
Main Authors: FUXE, K., ÖGREN, S.-O., JANSSON, A., CINTRA, A., HÄRFSTRAND, A., AGNATI, L. F.
Format: Article
Language:English
Subjects:
Animals
Biochemistry and metabolism
Biological and medical sciences
brain
Central nervous system
Fundamental and applied biological sciences. Psychology
Galanin
Hippocampus - metabolism
Injections, Intraventricular
Limbic System - metabolism
Male
metabolism
Parietal Lobe - metabolism
Peptides - administration & dosage
rat
Rats
Rats, Inbred Strains
serotonin
Serotonin - metabolism
Vertebrates: nervous system and sense organs
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Summary:To understand the role of galanin in the 5-hydroxytryptamine (5-HT) neurons the authors have investigated possible galanin/5-HT interactions at the presynaptic level by analysing the effects of intraventricular injections of galanin on 5-HT levels and metabolism in various cortical regions of the male rat. The present results indicate that the intraventricular injections of subnanomolar amounts of galanin in the awake unrestrained male rat reduces 5-HT metabolism, as evaluated from the ratio 5-HIAA/5-HT in the frontoparietal cortex, in the hippocampal formation and in the ventral limbic cortex.
ISSN:0001-6772
1365-201X
DOI:10.1111/j.1748-1716.1988.tb08444.x