Activation of a Plasmodium falciparum protease correlated with merozoite maturation and erythrocyte invasion

Protease‐dependent processes of the P. falciparum schizogonic cycle are briefly described. The P. falciparum p76 protease is the first example of a biochemically regulated protease, the activation of which is related to merozoite maturation and/or erythrocyte invasion. The main known properties of t...

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Bibliographic Details
Published in:Biology of the cell 1988, Vol.64 (2), p.223-231
Main Authors: Braun-Breton, Catherine, Da Silva, Luis Pereira
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Cell Fractionation
Dogs
Enzyme Activation
Erythrocytes - parasitology
Fundamental and applied biological sciences. Psychology
malaria
membrane
Membrane Proteins - biosynthesis
Membrane Proteins - immunology
Microsomes - drug effects
Pancreas - drug effects
Peptide Hydrolases - metabolism
Plasmodium
Plasmodium falciparum - enzymology
Plasmodium falciparum - growth & development
Precipitin Tests
protease
Protein Biosynthesis
Protozoa
RNA - isolation & purification
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Description
Summary:Protease‐dependent processes of the P. falciparum schizogonic cycle are briefly described. The P. falciparum p76 protease is the first example of a biochemically regulated protease, the activation of which is related to merozoite maturation and/or erythrocyte invasion. The main known properties of the p76 protease are reviewed and some original results concerning its biosynthesis and biological properties are described.
ISSN:0248-4900
1768-322X
DOI:10.1016/0248-4900(88)90081-0