Calcium antagonist treatment and cardiovascular responses to a cold pressor test at high altitude

We assessed the effects of the calcium antagonist felodipine on blood pressure, heart rate, oxygen saturation and cardiovascular responses to a cold pressor test at an altitude of 5200 m. Sixteen healthy climbers participated. A double-blind, placebo-controlled, randomized, crossover design was used...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1996, Vol.51 (3-4), p.265-267
Main Authors: HANKØ, E, ROSTRUP, M
Format: Article
Language:English
Subjects:
Adult
Altitude
Biological and medical sciences
Calcium Channel Blockers - pharmacology
Cold Temperature
Cross-Over Studies
Double-Blind Method
Drug toxicity and drugs side effects treatment
Felodipine - pharmacology
Female
Hemodynamics - drug effects
Humans
Male
Medical sciences
Oxygen - metabolism
Pharmacology. Drug treatments
Toxicity: cardiovascular system
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Summary:We assessed the effects of the calcium antagonist felodipine on blood pressure, heart rate, oxygen saturation and cardiovascular responses to a cold pressor test at an altitude of 5200 m. Sixteen healthy climbers participated. A double-blind, placebo-controlled, randomized, crossover design was used. Placebo or felodipine were taken for 2 days and the treatment was changed after 3 days washout. During felodipine treatment there were no significant changes in blood pressure (125/89 vs 127/86 mmHg), heart rate (82 vs 81 beats.min-1) or oxygen saturation (86% vs 86%). Moreover, there were no changes in the cardiovascular responses to the cold pressor test. Felodipine is well tolerated at high altitude. It does not induce hypotension in normotensive men and does not affect cardiovascular reactivity to cold stress.
ISSN:0031-6970
1432-1041
DOI:10.1007/s002280050195