Worm kinetics and serum IgE in Hooded Lister rats infected with the acanthocephalan Moniliformis moniliformis and the nematode Nippostrongylus brasiliensis

After infection with the intestinal helminths Moniliformis moniliformis or Nippostrongylus brasiliensis, worm-specific IgE first appeared in the serum of rats between days 10 and 24 p.i., varying with host age, worm species and worm dose used. The rate of increase in specific IgE was comparable rega...

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Bibliographic Details
Published in:International journal for parasitology 1996-11, Vol.26 (11), p.1287-1294
Main Authors: Hindsbo, Ole, Andersen, Per Aagåard, Lind, Peter
Format: Article
Language:English
Subjects:
Aging
Animals
Anthelmintics - therapeutic use
Antibodies, Helminth - blood
Antibody Formation
Biological and medical sciences
Diseases caused by nematodes
gut lumen helminths
Helminthiasis - drug therapy
Helminthiasis - immunology
Helminthiasis - physiopathology
Helminthic diseases
host age
IgE
Immunoglobulin E - blood
Infectious diseases
Kinetics
Male
Medical sciences
Miscellaneous
Moniliformis
Moniliformis - immunology
Moniliformis - isolation & purification
Moniliformis - physiology
Nippostrongylus
Nippostrongylus - immunology
Nippostrongylus - isolation & purification
Nippostrongylus - physiology
Oxyclozanide - therapeutic use
Parasitic diseases
Rats
Rats, Inbred Strains
Strongylida Infections - drug therapy
Strongylida Infections - immunology
Strongylida Infections - physiopathology
Time Factors
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Summary:After infection with the intestinal helminths Moniliformis moniliformis or Nippostrongylus brasiliensis, worm-specific IgE first appeared in the serum of rats between days 10 and 24 p.i., varying with host age, worm species and worm dose used. The rate of increase in specific IgE was comparable regardless of the worm species, infection dose or host age and a peak response was observed about 1 month after the sera turned positive. In the M. moniliformis infections, these events took place long before the beginning of worm expulsion on day 63 in high-dose (50 worms) infections, and potentiation of heterologous IgE was not observed. In contrast, IgE stimulation by N. brasiliensis infections was detected as potentiation of anti-ovalbumin IgE, anti- M. moniliformis IgE and total IgE. Most of the total IgE in the serum of M. moniliformis-infected rats was likely to be the worm-specific IgE. Anthelminthic removal of M. moniliformis revealed that the presence of residual worms was necessary to maintain worm-specific IgE production.
ISSN:0020-7519
1879-0135
DOI:10.1016/S0020-7519(96)00129-4