A tumor preventive effect of dietary restriction is antagonized by a high housing temperature through deprivation of torpor

Energy restriction (ER) has proven to be the only effective means of retarding aging in mice. The mechanisms of multiplicity of effects of ER on aging remain, however, fragmentary. ER induces daily torpor, the induction of which is reduced by increasing the ambient temperature to 30°C. The effects o...

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Bibliographic Details
Published in:Mechanisms of ageing and development 1996-11, Vol.92 (1), p.67-82
Main Authors: Koizumi, Akio, Wada, Yasuhiko, Tuskada, Mikako, Kayo, Tsuyoshi, Naruse, Mayumi, Horiuchi, Kazuyuki, Mogi, Takashi, Yoshioka, Masato, Sasaki, Masahiro, Miyamaura, Yoshinori, Abe, Tatsuya, Ohtomo, Kazuo, Walford, Roy L.
Format: Article
Language:English
Subjects:
Aging
Aging - physiology
Animals
Biological and medical sciences
Body Weight - physiology
C57BL/6
Carcinogenesis, carcinogens and anticarcinogens
Energy restriction
fas antigen
Female
Food Deprivation - physiology
Foods and miscellaneous
hypothermia
Lymphoma
Lymphoma - prevention & control
Male
Medical sciences
Mice
MRL/lrp mice
Temperature
Torpor prevention
Tumors
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Summary:Energy restriction (ER) has proven to be the only effective means of retarding aging in mice. The mechanisms of multiplicity of effects of ER on aging remain, however, fragmentary. ER induces daily torpor, the induction of which is reduced by increasing the ambient temperature to 30°C. The effects of preventing hypothermia in ER animals were studied in terms of the expected consequences of ER on survival, disease pattern and a number of physiological parameters in autoimmune prone MRL/lpr mice and lymphoma prone C57BL/6 mice. The results demonstrate that torpor plays a crucial role in the prevention of lymphoma development but does not have an affect on other aspects of ER, such as prevention of autoimmune diseases.
ISSN:0047-6374
1872-6216
DOI:10.1016/S0047-6374(96)01803-9