A tumor preventive effect of dietary restriction is antagonized by a high housing temperature through deprivation of torpor

• Published in: Mechanisms of ageing and development 1996-11, Vol.92 (1), p.67-82
• Main Authors: Koizumi, Akio, Wada, Yasuhiko, Tuskada, Mikako, Kayo, Tsuyoshi, Naruse, Mayumi, Horiuchi, Kazuyuki, Mogi, Takashi, Yoshioka, Masato, Sasaki, Masahiro, Miyamaura, Yoshinori, Abe, Tatsuya, Ohtomo, Kazuo, Walford, Roy L.
• Format: Article
• Language: English
• Subjects: Aging; Aging - physiology; Animals; Biological and medical sciences; Body Weight - physiology; C57BL/6; Carcinogenesis, carcinogens and anticarcinogens; Energy restriction; fas antigen; Female; Food Deprivation - physiology; Foods and miscellaneous; hypothermia; Lymphoma; Lymphoma - prevention & control; Male; Medical sciences; Mice; MRL/lrp mice; Temperature; Torpor prevention; Tumors
• ISSN: 0047-6374; 1872-6216
• DOI: 10.1016/S0047-6374(96)01803-9

Energy restriction (ER) has proven to be the only effective means of retarding aging in mice. The mechanisms of multiplicity of effects of ER on aging remain, however, fragmentary. ER induces daily torpor, the induction of which is reduced by increasing the ambient temperature to 30°C. The effects of preventing hypothermia in ER animals were studied in terms of the expected consequences of ER on survival, disease pattern and a number of physiological parameters in autoimmune prone MRL/lpr mice and lymphoma prone C57BL/6 mice. The results demonstrate that torpor plays a crucial role in the prevention of lymphoma development but does not have an affect on other aspects of ER, such as prevention of autoimmune diseases.