Correlation between glomerular morphology and renal haemodynamic response to amino-acid administration in patients with IgA nephropathy

• Published in: Nephrology, dialysis, transplantation dialysis, transplantation, 1996-12, Vol.11 (12), p.2421-2425
• Main Authors: Pluvio, C., de Pascale, E., Giordano, M., Cirillo, D., Carone, M., Pluvio, M., Castellino, P., Giordano, C.
• Format: Article
• Language: English
• Subjects: Adult; amino acid; Amino Acids - administration & dosage; Amino Acids - blood; Biological and medical sciences; Blood Pressure; Fasting; GFR; Glomerular Filtration Rate; Glomerulonephritis; Glomerulonephritis, IGA - blood; Glomerulonephritis, IGA - etiology; Glomerulonephritis, IGA - physiopathology; Glucagon - blood; Heart Rate; Hemodynamics - drug effects; Humans; IgA nephropathy; Infusions, Intravenous; Insulin - blood; Kidney - physiology; Kidney Glomerulus - pathology; Medical sciences; Nephrology. Urinary tract diseases; Nephropathies. Renovascular diseases. Renal failure; p-Aminohippuric Acid - blood; renal biopsy; Renal Plasma Flow; RPF; Vascular Resistance
• ISSN: 0931-0509; 1460-2385
• DOI: 10.1093/oxfordjournals.ndt.a027208

Rationale. To establish relationship, if any, between renal morphology and renal haemodynamic response to amino acids. Design and methods. We investigated the correlation between renal haemodynamic regulation and morphology in a group of 15 patients with primary IgA nephropathy (IgAN) (age 26±2 years, BMI 24.4±1, GFR 64±5 ml/min, RPF 377±34 mI/mm, FF 0.17±0.02). Twelve normal subjects (age 30±3 years, BMI 24±1, GFR 82±6 ml/min, RPF421±42 ml/min, FF 0.19±0.02) were studied as controls. IgA patients were divided into two groups according to the histological staging of glomerular lesions: group I (n=7) stage II, and group II (n=8) stage III–IV. Results. In the basal state GFR was similar in the two groups and averaged 64±9 and 64±6 ml/mm respectively. In contrast, FF was significantly lower in group II(0.14±0.01) (P