Frequency of medically attended events following rapid revaccination with trivalent inactivated influenza vaccine

Abstract In 2008, potential temperature compromise of one lot of trivalent inactivated influenza vaccine (TIV) led to the revaccination of 13,210 Kaiser Permanente Northwest members within 28 days of receipt of their initial TIV dose. We conducted a retrospective cohort study to determine if these i...

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Bibliographic Details
Published in:Vaccine 2010-11, Vol.28 (49), p.7713-7715
Main Authors: Schmidt, Mark A, Crane, Brad, Mullooly, John P, Naleway, Allison L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Allergy and Immunology
Applied microbiology
Biological and medical sciences
Child
Cohort Studies
Female
Fundamental and applied biological sciences. Psychology
Humans
Immunization
Immunization, Secondary
Influenza
Influenza Vaccines - administration & dosage
Influenza Vaccines - adverse effects
Influenza, Human - prevention & control
Male
Medically attended events
Microbiology
Middle Aged
Retrospective Studies
Studies
Trivalent influenza vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - adverse effects
Young Adult
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Summary:Abstract In 2008, potential temperature compromise of one lot of trivalent inactivated influenza vaccine (TIV) led to the revaccination of 13,210 Kaiser Permanente Northwest members within 28 days of receipt of their initial TIV dose. We conducted a retrospective cohort study to determine if these individuals experienced a higher rate of medically attended events (MAE) than those receiving only one TIV dose. We found no increase in MAE among those rapidly revaccinated (odds ratio 1.08; 95% confidence interval 0.80, 1.45), which may reassure individuals of the safety of revaccination with TIV should it be necessary, thereby leading to increased compliance with influenza vaccination recommendations.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2010.09.043