Functional effects of cancer mitochondria on energy metabolism and tumorigenesis: utility of transmitochondrial cybrids

Reprogramming of energy metabolism is one of the hallmarks of cancer. In normal conditions, cells rely on mitochondrial oxidative phosphorylation to provide energy for cellular activities. Cancer cells are characterized by increased glycolysis and reduced mitochondrial respiratory function. In the p...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2010-07, Vol.1201 (1), p.137-146
Main Authors: Kaipparettu, Benny Abraham, Ma, Yewei, Wong, Lee-Jun C.
Format: Article
Language:English
Subjects:
Animals
Breast Neoplasms - genetics
Breast Neoplasms - metabolism
Cancer
cancer mitochondria: altered mitochondria in breast cancer
Cell Line, Tumor
Cellular
Chains
DNA, Mitochondrial - metabolism
dual genome cross-talk
Energy Metabolism
Gene Deletion
Gene Expression Regulation, Neoplastic
HeLa Cells
Humans
In vitro testing
Medical research
Metabolism
Mice
Mitochondria
Mitochondria - metabolism
Mitochondrial DNA
Models, Biological
Neoplasms - genetics
Neoplasms - metabolism
Phosphorylation
Risk
Surgical implants
transmitochondrial cybrid
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Summary:Reprogramming of energy metabolism is one of the hallmarks of cancer. In normal conditions, cells rely on mitochondrial oxidative phosphorylation to provide energy for cellular activities. Cancer cells are characterized by increased glycolysis and reduced mitochondrial respiratory function. In the past decade, somatic mitochondrial DNA alterations are found to be common in all types of cancers. However, the functional significance of the altered cancer mitochondria is largely unknown. This is because the bulk of cancer properties are regulated by nuclear encoded genes. To overcome this problem, the transmitochondrial cybrid system, which allows the study of the effect of cancer mitochondria in a common nuclear background, has been used. Here we review the accumulating evidence that altered cancer mitochondria affect the respiratory chain function and oncogenic properties in vitro and in vivo using cybrid technologies.
ISSN:0077-8923
1749-6632
DOI:10.1111/j.1749-6632.2010.05621.x