Diversity of glutamate receptors in neocortical neurons: Implications for synaptic plasticity

The biochemical and functional characteristics of the AMPA subtype of the glutamate receptors expressed by pyramidal and non-pyramidal neurons of the neocortex have been studied in acute slices by means of single-cell RT-PCR and fast applications of glutamate on outside-out patches. Our results sugg...

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Bibliographic Details
Published in:Journal of physiology, Paris Paris, 1996, Vol.90 (5), p.331-332
Main Authors: Audinat, E, Lambolez, B, Cauli, B, Ropert, N, Perrais, D, Hestrin, S, Rossier, J
Format: Article
Language:English
Subjects:
Alternative Splicing
AMPA receptor
Animals
Cerebral Cortex - physiology
desensitization
fast-spiking cell
Genetic Variation
In Vitro Techniques
Macromolecular Substances
mRNA
neocortex
Neuronal Plasticity
Neurons - physiology
Polymerase Chain Reaction
pyramidal cell
Receptors, AMPA - biosynthesis
Receptors, AMPA - physiology
single-cell RT-PCR
Somatosensory Cortex - physiology
Synapses - physiology
Visual Cortex - physiology
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Summary:The biochemical and functional characteristics of the AMPA subtype of the glutamate receptors expressed by pyramidal and non-pyramidal neurons of the neocortex have been studied in acute slices by means of single-cell RT-PCR and fast applications of glutamate on outside-out patches. Our results suggest that the predominant expression of the flop splice variants of the GluR1-4 AMPA subunits contributes to the faster desensitization of these receptors in non-pyramidal neurons compared to pyramidal cells where flip variants of GluR1-4 are dominant. Alternative splicing of AMPA receptors may therefore play an important role in regulating synaptic function in a cell-type specific manner.
ISSN:0928-4257
1769-7115
DOI:10.1016/S0928-4257(97)87911-9