Electrospun Silk Material Systems for Wound Healing

The functional properties of six distinct electrospun silk material groups were evaluated to assess conformational and biocompatible characteristics related to wound dressings. In a hydrated state, all six silk matrices exhibited absorption, water vapor transmission, oxygen permeation and enzymatic...

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Bibliographic Details
Published in:Macromolecular bioscience 2010-03, Vol.10 (3), p.246-257
Main Authors: Wharram, Scott E., Zhang, Xiaohui, Kaplan, David L., McCarthy, Stephen P.
Format: Article
Language:English
Subjects:
Absorption - drug effects
Animals
Applied sciences
Biocompatible Materials - pharmacology
Biological and medical sciences
Biomaterials
Bombyx
Chitosan - pharmacology
Constraints
crystallization
Electrospinning
Exact sciences and technology
gas transmission
Materials Testing - methods
Matrices
Medical sciences
Microscopy, Atomic Force
Natural polymers
Oxygen - analysis
Permeation
Physicochemistry of polymers
poly(ethylene oxide)
Porosity - drug effects
Proteins
Silk
Silk - pharmacology
Silk - ultrastructure
Surface Properties - drug effects
Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases
Surgical implants
Technology. Biomaterials. Equipments
Water vapor
wound healing
Wound Healing - drug effects
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Summary:The functional properties of six distinct electrospun silk material groups were evaluated to assess conformational and biocompatible characteristics related to wound dressings. In a hydrated state, all six silk matrices exhibited absorption, water vapor transmission, oxygen permeation and enzymatic biodegradation suitable for full‐thickness wound sites. Employing constrained drying techniques, silk concentration was a determinate factor influencing material structural properties related to the storage and distribution of such wound dressing systems. Subsequently, three electrospun silk models demonstrated ideal biomaterial properties with potential utility for wound dressings. The conformational and biofunctional properties of three distinct electrospun silk material groups produce a wound dressing with a sustainable shelf life, provide an impermeable barrier to bacilli and cocci sepsis initiating bacterial pathogens, enable management of wound site edema and dehydration and support time synchronized antibiotic, immunological, and tissue regeneration biotherapies.
ISSN:1616-5187
1616-5195
DOI:10.1002/mabi.200900274