Multi-variate analysis of factors governing the pharmacokinetics of exogenous factor VIII in haemophiliacs

The pharmacokinetics of Factor VIII was evaluated by mathematical modeling in a large-scale study in 62 haemophilia-A subjects, in whom 137 plasma Factor VIII-time curves were measured during single dose (n = 87) and repeated-dose (n = 47) treatments for prophylaxis or minor bleeding episodes. The p...

Full description

Saved in:
Bibliographic Details
Published in:European journal of clinical pharmacology 1988-01, Vol.35 (6), p.663-668
Main Authors: MESSORI, A, LONGO, G, MORFINI, M, CINOTTI, S, FILIMBERTI, E, GIUSTARINI, G, ROSSI FERRINI, P
Format: Article
Language:English
Subjects:
Adolescent
Adult
Age Factors
Aged
Analysis of Variance
Biological and medical sciences
Blood. Blood coagulation. Reticuloendothelial system
Body Weight
Child
Child, Preschool
Dose-Response Relationship, Drug
Factor VIII - administration & dosage
Factor VIII - pharmacokinetics
Hemophilia A - blood
Humans
Infant
Medical sciences
Middle Aged
Pharmacology. Drug treatments
Statistics as Topic
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The pharmacokinetics of Factor VIII was evaluated by mathematical modeling in a large-scale study in 62 haemophilia-A subjects, in whom 137 plasma Factor VIII-time curves were measured during single dose (n = 87) and repeated-dose (n = 47) treatments for prophylaxis or minor bleeding episodes. The pharmacokinetic parameters [mean (SD)] estimated from single-dose curves were: clearance 3.85 ml.h-1.kg-1, volume of distribution 58.2 ml.kg-1, mean residence time 15.9 h. Parameters calculated from repeated-dose curves were: clearance 3.93 ml.h-1.kg-1, volume of distribution 61.8 ml.kg-1, and half-life 12.2 h. In patients with mild haemophilia, pharmaco-statistical analysis revealed that the endogenous synthesis of Factor VIII was constant and was not influenced by the administration of exogenous Factor VIII. The coefficient of variation for intra-individual variability of Factor VIII kinetics (estimated according to the Standard Two-Stage method) was 20.7% in single-dose curves and 23.2% in repeated-dose curves.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00637604