Piroxicam in breast milk after long-term treatment

The presence of piroxicam in breast milk was determined by HPTLC during initial and long term dosing in 4 women treated for arthritis. Piroxicam appeared in breast milk at about 1-3% of the maternal plasma concentration. No accumulation of piroxicam occurred in milk relative to that in plasma up to...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1988-01, Vol.35 (5), p.567-569
Main Authors: ØSTENSEN, M, MATHESON, I, LAUFEN, H
Format: Article
Language:English
Subjects:
Adult
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - metabolism
Biological and medical sciences
Bones, joints and connective tissue. Antiinflammatory agents
Female
Humans
Medical sciences
Milk, Human - metabolism
Pharmacology. Drug treatments
Piroxicam - administration & dosage
Piroxicam - blood
Piroxicam - pharmacokinetics
Pregnancy
Puerperal Disorders - drug therapy
Puerperal Disorders - metabolism
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Summary:The presence of piroxicam in breast milk was determined by HPTLC during initial and long term dosing in 4 women treated for arthritis. Piroxicam appeared in breast milk at about 1-3% of the maternal plasma concentration. No accumulation of piroxicam occurred in milk relative to that in plasma up to 52 days of treatment. Neither piroxicam nor its conjugates were detectable in the urine of one breast-fed infant. The daily dose ingested by the infant was calculated to average 3.5% (maximum 6.3%) of the weight-related maternal dose of piroxicam. It is concluded that a breast-fed infant will be exposed to a very small amount of piroxicam.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00558255