Arachidonic Acid Activation of Monocyte and Neutrophil Reactive Oxygen in Lung Cancer Patients Undergoing Pulmonary Resection

Reactive oxygen (roi) generation was investigated in phagocyted of 39 patients undergoing pulmonary resection for lung cancer and 39 paired healthy controls. Generation of roi in monocytes and neutrophils was monitored using 2′, 7′-dichlorofluorescein diacetate. Activation associated with hydrophobi...

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Bibliographic Details
Published in:Biologicals 1996-12, Vol.24 (4), p.319-324
Main Authors: Leaver, H.A., Craig, S.R., Yap, P.L., Williams, J.R., Walker, W.S.
Format: Article
Language:English
Subjects:
Arachidonic Acid - pharmacology
Carcinoma, Bronchogenic - blood
Carcinoma, Bronchogenic - pathology
Carcinoma, Bronchogenic - surgery
gamma-Linolenic Acid - pharmacology
Humans
Lung Neoplasms - blood
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Monocytes - drug effects
Monocytes - metabolism
Monocytes - pathology
Neutrophils - drug effects
Neutrophils - metabolism
Neutrophils - pathology
Pneumonectomy
Postoperative Period
Reactive Oxygen Species - metabolism
Respiratory Burst - drug effects
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Summary:Reactive oxygen (roi) generation was investigated in phagocyted of 39 patients undergoing pulmonary resection for lung cancer and 39 paired healthy controls. Generation of roi in monocytes and neutrophils was monitored using 2′, 7′-dichlorofluorescein diacetate. Activation associated with hydrophobic interactions was probed by analysis of phagocyte roi activation by arachidonic acid and γ-linolenic acid. Patient roi was measured pre-operatively and 2 and 7 days post-operatively. Elevated (P
ISSN:1045-1056
1095-8320
DOI:10.1006/biol.1996.0044