Arachidonic Acid Activation of Monocyte and Neutrophil Reactive Oxygen in Lung Cancer Patients Undergoing Pulmonary Resection

Reactive oxygen (roi) generation was investigated in phagocyted of 39 patients undergoing pulmonary resection for lung cancer and 39 paired healthy controls. Generation of roi in monocytes and neutrophils was monitored using 2′, 7′-dichlorofluorescein diacetate. Activation associated with hydrophobi...

Full description

Saved in:
Bibliographic Details
Published in:Biologicals 1996-12, Vol.24 (4), p.319-324
Main Authors: Leaver, H.A., Craig, S.R., Yap, P.L., Williams, J.R., Walker, W.S.
Format: Article
Language:English
Subjects:
Arachidonic Acid - pharmacology
Carcinoma, Bronchogenic - blood
Carcinoma, Bronchogenic - pathology
Carcinoma, Bronchogenic - surgery
gamma-Linolenic Acid - pharmacology
Humans
Lung Neoplasms - blood
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Monocytes - drug effects
Monocytes - metabolism
Monocytes - pathology
Neutrophils - drug effects
Neutrophils - metabolism
Neutrophils - pathology
Pneumonectomy
Postoperative Period
Reactive Oxygen Species - metabolism
Respiratory Burst - drug effects
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c405t-dc7366c62be794cd30e7b5f89193056f98402e9cf96191b0b39608157bb9de7e3
cites
container_end_page 324
container_issue 4
container_start_page 319
container_title Biologicals
container_volume 24
creator Leaver, H.A.
Craig, S.R.
Yap, P.L.
Williams, J.R.
Walker, W.S.
description Reactive oxygen (roi) generation was investigated in phagocyted of 39 patients undergoing pulmonary resection for lung cancer and 39 paired healthy controls. Generation of roi in monocytes and neutrophils was monitored using 2′, 7′-dichlorofluorescein diacetate. Activation associated with hydrophobic interactions was probed by analysis of phagocyte roi activation by arachidonic acid and γ-linolenic acid. Patient roi was measured pre-operatively and 2 and 7 days post-operatively. Elevated (P
doi_str_mv 10.1006/biol.1996.0044
format article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78718140</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1045105696900445</els_id><sourcerecordid>78718140</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-dc7366c62be794cd30e7b5f89193056f98402e9cf96191b0b39608157bb9de7e3</originalsourceid><addsrcrecordid>eNp1kDFv2zAQhYkgQZKmWbMF4NRN7tGiKHI0jCYt4DZGUM-ERJ4cBjLpklIQD_3vpWCjW5bjAe_dO95HyB2DGQMQX1sX-hlTSswAOD8j1wxUVchyDudTz6uCQSWuyKeUXgEY4zW_JJcKpKy4uCZ_F7ExL84G7wxdGGdzGdxbM7jgaejoz-CDOQxIG2_pLxyHGPYvrqfP2Ew-pE_vhy166jxdjX5Ll403GOk6B6AfEt14i3EbXJbWY78LvomHPJzQTBs-k4uu6RPent4bsnn49nv5vVg9Pf5YLlaF4VANhTV1KYQR8xZrxY0tAeu26qRiqszHdUpymKMynRJMsRbaUgmQrKrbVlmssbwhX465-xj-jJgGvXPJYN83HsOYdC1rJhmHbJwdjSaGlCJ2eh_dLv9ZM9ATbz3x1hNvPfHOA_en5LHdof1vPwHOujzqmM97cxh1MpmMQetiZqBtcB9F_wMkwpB4</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>78718140</pqid></control><display><type>article</type><title>Arachidonic Acid Activation of Monocyte and Neutrophil Reactive Oxygen in Lung Cancer Patients Undergoing Pulmonary Resection</title><source>ScienceDirect Freedom Collection</source><creator>Leaver, H.A. ; Craig, S.R. ; Yap, P.L. ; Williams, J.R. ; Walker, W.S.</creator><creatorcontrib>Leaver, H.A. ; Craig, S.R. ; Yap, P.L. ; Williams, J.R. ; Walker, W.S.</creatorcontrib><description>Reactive oxygen (roi) generation was investigated in phagocyted of 39 patients undergoing pulmonary resection for lung cancer and 39 paired healthy controls. Generation of roi in monocytes and neutrophils was monitored using 2′, 7′-dichlorofluorescein diacetate. Activation associated with hydrophobic interactions was probed by analysis of phagocyte roi activation by arachidonic acid and γ-linolenic acid. Patient roi was measured pre-operatively and 2 and 7 days post-operatively. Elevated (P&lt;0.01) roi productin was detected in neutrophils of lung cancer patients. surgery was associated with an increase (P&lt;0.05–P&lt;0.01) in phagocyte roi at 2 and 7 days post-op. Phagocyte roi was stimulated by arachidonic acid and γ-linolenic acid (1–40 μM) both pre- and post-operatively. Differences in arachidonic acid and γ-linolenic acid stimulation between patient and control and pre- and post-op patient phagocyted suggest arachidonic acid involvement in phagocyte activation during reactive responses to lung carcinoma and surgery.</description><identifier>ISSN: 1045-1056</identifier><identifier>EISSN: 1095-8320</identifier><identifier>DOI: 10.1006/biol.1996.0044</identifier><identifier>PMID: 9088546</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Arachidonic Acid - pharmacology ; Carcinoma, Bronchogenic - blood ; Carcinoma, Bronchogenic - pathology ; Carcinoma, Bronchogenic - surgery ; gamma-Linolenic Acid - pharmacology ; Humans ; Lung Neoplasms - blood ; Lung Neoplasms - pathology ; Lung Neoplasms - surgery ; Monocytes - drug effects ; Monocytes - metabolism ; Monocytes - pathology ; Neutrophils - drug effects ; Neutrophils - metabolism ; Neutrophils - pathology ; Pneumonectomy ; Postoperative Period ; Reactive Oxygen Species - metabolism ; Respiratory Burst - drug effects</subject><ispartof>Biologicals, 1996-12, Vol.24 (4), p.319-324</ispartof><rights>1997 The International Association for Biologicals</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-dc7366c62be794cd30e7b5f89193056f98402e9cf96191b0b39608157bb9de7e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9088546$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leaver, H.A.</creatorcontrib><creatorcontrib>Craig, S.R.</creatorcontrib><creatorcontrib>Yap, P.L.</creatorcontrib><creatorcontrib>Williams, J.R.</creatorcontrib><creatorcontrib>Walker, W.S.</creatorcontrib><title>Arachidonic Acid Activation of Monocyte and Neutrophil Reactive Oxygen in Lung Cancer Patients Undergoing Pulmonary Resection</title><title>Biologicals</title><addtitle>Biologicals</addtitle><description>Reactive oxygen (roi) generation was investigated in phagocyted of 39 patients undergoing pulmonary resection for lung cancer and 39 paired healthy controls. Generation of roi in monocytes and neutrophils was monitored using 2′, 7′-dichlorofluorescein diacetate. Activation associated with hydrophobic interactions was probed by analysis of phagocyte roi activation by arachidonic acid and γ-linolenic acid. Patient roi was measured pre-operatively and 2 and 7 days post-operatively. Elevated (P&lt;0.01) roi productin was detected in neutrophils of lung cancer patients. surgery was associated with an increase (P&lt;0.05–P&lt;0.01) in phagocyte roi at 2 and 7 days post-op. Phagocyte roi was stimulated by arachidonic acid and γ-linolenic acid (1–40 μM) both pre- and post-operatively. Differences in arachidonic acid and γ-linolenic acid stimulation between patient and control and pre- and post-op patient phagocyted suggest arachidonic acid involvement in phagocyte activation during reactive responses to lung carcinoma and surgery.</description><subject>Arachidonic Acid - pharmacology</subject><subject>Carcinoma, Bronchogenic - blood</subject><subject>Carcinoma, Bronchogenic - pathology</subject><subject>Carcinoma, Bronchogenic - surgery</subject><subject>gamma-Linolenic Acid - pharmacology</subject><subject>Humans</subject><subject>Lung Neoplasms - blood</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - surgery</subject><subject>Monocytes - drug effects</subject><subject>Monocytes - metabolism</subject><subject>Monocytes - pathology</subject><subject>Neutrophils - drug effects</subject><subject>Neutrophils - metabolism</subject><subject>Neutrophils - pathology</subject><subject>Pneumonectomy</subject><subject>Postoperative Period</subject><subject>Reactive Oxygen Species - metabolism</subject><subject>Respiratory Burst - drug effects</subject><issn>1045-1056</issn><issn>1095-8320</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><recordid>eNp1kDFv2zAQhYkgQZKmWbMF4NRN7tGiKHI0jCYt4DZGUM-ERJ4cBjLpklIQD_3vpWCjW5bjAe_dO95HyB2DGQMQX1sX-hlTSswAOD8j1wxUVchyDudTz6uCQSWuyKeUXgEY4zW_JJcKpKy4uCZ_F7ExL84G7wxdGGdzGdxbM7jgaejoz-CDOQxIG2_pLxyHGPYvrqfP2Ew-pE_vhy166jxdjX5Ll403GOk6B6AfEt14i3EbXJbWY78LvomHPJzQTBs-k4uu6RPent4bsnn49nv5vVg9Pf5YLlaF4VANhTV1KYQR8xZrxY0tAeu26qRiqszHdUpymKMynRJMsRbaUgmQrKrbVlmssbwhX465-xj-jJgGvXPJYN83HsOYdC1rJhmHbJwdjSaGlCJ2eh_dLv9ZM9ATbz3x1hNvPfHOA_en5LHdof1vPwHOujzqmM97cxh1MpmMQetiZqBtcB9F_wMkwpB4</recordid><startdate>19961201</startdate><enddate>19961201</enddate><creator>Leaver, H.A.</creator><creator>Craig, S.R.</creator><creator>Yap, P.L.</creator><creator>Williams, J.R.</creator><creator>Walker, W.S.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>19961201</creationdate><title>Arachidonic Acid Activation of Monocyte and Neutrophil Reactive Oxygen in Lung Cancer Patients Undergoing Pulmonary Resection</title><author>Leaver, H.A. ; Craig, S.R. ; Yap, P.L. ; Williams, J.R. ; Walker, W.S.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-dc7366c62be794cd30e7b5f89193056f98402e9cf96191b0b39608157bb9de7e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>Arachidonic Acid - pharmacology</topic><topic>Carcinoma, Bronchogenic - blood</topic><topic>Carcinoma, Bronchogenic - pathology</topic><topic>Carcinoma, Bronchogenic - surgery</topic><topic>gamma-Linolenic Acid - pharmacology</topic><topic>Humans</topic><topic>Lung Neoplasms - blood</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - surgery</topic><topic>Monocytes - drug effects</topic><topic>Monocytes - metabolism</topic><topic>Monocytes - pathology</topic><topic>Neutrophils - drug effects</topic><topic>Neutrophils - metabolism</topic><topic>Neutrophils - pathology</topic><topic>Pneumonectomy</topic><topic>Postoperative Period</topic><topic>Reactive Oxygen Species - metabolism</topic><topic>Respiratory Burst - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leaver, H.A.</creatorcontrib><creatorcontrib>Craig, S.R.</creatorcontrib><creatorcontrib>Yap, P.L.</creatorcontrib><creatorcontrib>Williams, J.R.</creatorcontrib><creatorcontrib>Walker, W.S.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Biologicals</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leaver, H.A.</au><au>Craig, S.R.</au><au>Yap, P.L.</au><au>Williams, J.R.</au><au>Walker, W.S.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Arachidonic Acid Activation of Monocyte and Neutrophil Reactive Oxygen in Lung Cancer Patients Undergoing Pulmonary Resection</atitle><jtitle>Biologicals</jtitle><addtitle>Biologicals</addtitle><date>1996-12-01</date><risdate>1996</risdate><volume>24</volume><issue>4</issue><spage>319</spage><epage>324</epage><pages>319-324</pages><issn>1045-1056</issn><eissn>1095-8320</eissn><abstract>Reactive oxygen (roi) generation was investigated in phagocyted of 39 patients undergoing pulmonary resection for lung cancer and 39 paired healthy controls. Generation of roi in monocytes and neutrophils was monitored using 2′, 7′-dichlorofluorescein diacetate. Activation associated with hydrophobic interactions was probed by analysis of phagocyte roi activation by arachidonic acid and γ-linolenic acid. Patient roi was measured pre-operatively and 2 and 7 days post-operatively. Elevated (P&lt;0.01) roi productin was detected in neutrophils of lung cancer patients. surgery was associated with an increase (P&lt;0.05–P&lt;0.01) in phagocyte roi at 2 and 7 days post-op. Phagocyte roi was stimulated by arachidonic acid and γ-linolenic acid (1–40 μM) both pre- and post-operatively. Differences in arachidonic acid and γ-linolenic acid stimulation between patient and control and pre- and post-op patient phagocyted suggest arachidonic acid involvement in phagocyte activation during reactive responses to lung carcinoma and surgery.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>9088546</pmid><doi>10.1006/biol.1996.0044</doi><tpages>6</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1045-1056
ispartof Biologicals, 1996-12, Vol.24 (4), p.319-324
issn 1045-1056
1095-8320
language eng
recordid cdi_proquest_miscellaneous_78718140
source ScienceDirect Freedom Collection
subjects Arachidonic Acid - pharmacology
Carcinoma, Bronchogenic - blood
Carcinoma, Bronchogenic - pathology
Carcinoma, Bronchogenic - surgery
gamma-Linolenic Acid - pharmacology
Humans
Lung Neoplasms - blood
Lung Neoplasms - pathology
Lung Neoplasms - surgery
Monocytes - drug effects
Monocytes - metabolism
Monocytes - pathology
Neutrophils - drug effects
Neutrophils - metabolism
Neutrophils - pathology
Pneumonectomy
Postoperative Period
Reactive Oxygen Species - metabolism
Respiratory Burst - drug effects
title Arachidonic Acid Activation of Monocyte and Neutrophil Reactive Oxygen in Lung Cancer Patients Undergoing Pulmonary Resection
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T10%3A12%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Arachidonic%20Acid%20Activation%20of%20Monocyte%20and%20Neutrophil%20Reactive%20Oxygen%20in%20Lung%20Cancer%20Patients%20Undergoing%20Pulmonary%20Resection&rft.jtitle=Biologicals&rft.au=Leaver,%20H.A.&rft.date=1996-12-01&rft.volume=24&rft.issue=4&rft.spage=319&rft.epage=324&rft.pages=319-324&rft.issn=1045-1056&rft.eissn=1095-8320&rft_id=info:doi/10.1006/biol.1996.0044&rft_dat=%3Cproquest_cross%3E78718140%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c405t-dc7366c62be794cd30e7b5f89193056f98402e9cf96191b0b39608157bb9de7e3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=78718140&rft_id=info:pmid/9088546&rfr_iscdi=true