Phenobarbital adsorption from simulated intestinal fluid U.S.P., and simulated gastric fluid, U.S.P., by two activated charcoals

Adsorption of phenobarbital from simulated intestinal and gastric fluids by two activated charcoals was studied. Adsorption isotherm data were analyzed by the linearized Langmuir equation and by nonlinear least-squares regression employing both Langmuir and Freundlich models. These analyses indicate...

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Bibliographic Details
Published in:Pharmaceutical research 1988-03, Vol.5 (3), p.183-186
Main Authors: WURSTER, D. E, BURKE, G. M, BERG, M. J, VENG-PEDERSEN, P, SCHOTTELIUS, D. D
Format: Article
Language:English
Subjects:
Adsorption
Biological and medical sciences
Charcoal
Gastric Juice - metabolism
General pharmacology
Intestinal Secretions - metabolism
Medical sciences
Pharmacokinetics. Pharmacogenetics. Drug-receptor interactions
Pharmacology. Drug treatments
Phenobarbital - pharmacokinetics
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Summary:Adsorption of phenobarbital from simulated intestinal and gastric fluids by two activated charcoals was studied. Adsorption isotherm data were analyzed by the linearized Langmuir equation and by nonlinear least-squares regression employing both Langmuir and Freundlich models. These analyses indicated differences in the capacities of the two charcoals for phenobarbital which could not be completely explained by surface-area considerations.
ISSN:0724-8741
1573-904X
DOI:10.1023/A:1015969008019