The role of Src family kinases in the normal and neoplastic gastrointestinal tract

Src family kinases are a group of non-receptor tyrosine kinases that mediate signal transduction pathways involved in the growth and differentiation of normal tissues. Considerable evidence exists for a role of these proteins in neoplastic progression in various organ systems including the nervous,...

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Bibliographic Details
Published in:Surgical oncology 1996-10, Vol.5 (5), p.201-210
Main Authors: Banker, N., Evers, B.M., Hellmich, M.R., Townsend, C.M.
Format: Article
Language:English
Subjects:
Biomarkers, Tumor - analysis
Biomarkers, Tumor - biosynthesis
differentiation
Digestive System - enzymology
Gastrointestinal Neoplasms - diagnosis
Gastrointestinal Neoplasms - enzymology
gastrointestinal tract
growth
Humans
neoplasms
Sensitivity and Specificity
SH2
Signal Transduction - physiology
Src kinase
src-Family Kinases - metabolism
src-Family Kinases - physiology
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Summary:Src family kinases are a group of non-receptor tyrosine kinases that mediate signal transduction pathways involved in the growth and differentiation of normal tissues. Considerable evidence exists for a role of these proteins in neoplastic progression in various organ systems including the nervous, hematopoietic and skeletal systems. In addition, the role of the Src kinase family has been characterized for colon cancer, but only limited progress has been made in delineating the role of Src kinases in the normal gastrointestinal (GI) tract and extracolonic GI cancers. In this review, we provide an up-to-date assessment of the Src family kinases in the normal and neoplastic GI tract.
ISSN:0960-7404
1879-3320
DOI:10.1016/S0960-7404(96)80023-5