Immunosorbent for IgG apheresis: an in vitro study

We obtained anti-IgG Sepharose-an immunosorbent with sheep monospecific polyclonal antibodies against human IgG-for extracorporeal removal of human IgG. Appropriate conditions for effective usage of the immunosorbent were chosen. Binding capacity and selectivity of anti-IgG Sepharose were determined...

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Bibliographic Details
Published in:Transfusion science 1996-12, Vol.17 (4), p.519-525
Main Authors: Kiseleva, E A, Afanasieva, O I, Kosheleva, N A, Pokrovsky, S N
Format: Article
Language:English
Subjects:
Blood Component Removal
Health technology assessment
Humans
Immunoglobulin G - isolation & purification
Immunosorbent Techniques
Immunosorbents
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Summary:We obtained anti-IgG Sepharose-an immunosorbent with sheep monospecific polyclonal antibodies against human IgG-for extracorporeal removal of human IgG. Appropriate conditions for effective usage of the immunosorbent were chosen. Binding capacity and selectivity of anti-IgG Sepharose were determined and compared with the corresponding properties of other sorbents for IgG apheresis; these properties appeared to be acceptable for immunoapheresis procedures. Methods for therapeutic application of anti-IgG Sepharose is expected to be effective when used in immunoapheresis procedures for treatment of autoimmune diseases and for preparation of patients for organ transplantation.
ISSN:0955-3886
DOI:10.1016/S0955-3886(96)90087-9