Structurally homogeneous and heterogeneous synthetic combinatorial libraries

• Published in: Molecular diversity 1996-05, Vol.1 (3), p.149-164
• Main Authors: Krchnák, V, Weichsel, A S, Cabel, D, Flegelova, Z, Lebl, M
• Format: Article
• Language: English
• Subjects: Aldehydes - chemical synthesis; Aldehydes - chemistry; Amino Alcohols - chemical synthesis; Amino Alcohols - chemistry; Chemistry, Organic - methods; Directed Molecular Evolution - methods; Drug Design; Hydroxy Acids - chemical synthesis; Hydroxy Acids - chemistry; Molecular Structure
• ISSN: 1381-1991; 1573-501X
• DOI: 10.1007/BF01544953

We have designed and synthesized structurally homogeneous and heterogeneous nonpeptide libraries. Structurally homogeneous libraries are characterized by the presence of one common structural unit, a scaffold, in all library compounds (e.g. cyclopentane, cyclohexane, diketopiperazine, thiazolidine). In structurally heterogeneous libraries different organic reactions (acylation, etherification, reductive amination, nucleophilic displacement) were applied to connect bifunctional building blocks unrelated in structure (aromatic hydroxy acids, aromatic hydroxy aldehydes, amino alcohols, diamines, and amino acids). The focus of this communication is to document the use of bifunctional building blocks for the design and synthesis of structurally heterogeneous libraries of N-(alkoxy acyl)amino acids, N,N'-bis-(alkoxy acyl)diamino acids, N-acylamino ethers, N-(alkoxy acyl)amino alcohols, N-alkylamino ethers, and N-(alkoxy aryl)diamines.