Glutathione reductase during and after brain ischemia in gerbils

The activity of glutathione reductase (GR) was measured in crude mitochondrial fraction isolated from cerebral cortex and basal ganglia of Mongolian gerbils subjected to bilateral carotid occlusion of various duration (1, 2, 3, 5, 10, and 15 min), or reflow (1, 24, and 96 hr) following ischemia (5 o...

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Bibliographic Details
Published in:Metabolic brain disease 1988-12, Vol.3 (4), p.293-296
Main Authors: STANIMIROVIC, D, DJURICIC, B.M, MRSULJA, B.B
Format: Article
Language:English
Subjects:
Animals
Basal Ganglia - metabolism
Basal Ganglia - physiopathology
Biological and medical sciences
Cerebral Cortex - metabolism
Cerebral Cortex - physiopathology
Female
Gerbillinae
Glutathione Reductase - metabolism
Ischemic Attack, Transient - metabolism
Male
Medical sciences
Mitochondria - metabolism
Nervous system involvement in other diseases. Miscellaneous
Neurology
Subcellular Fractions - metabolism
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Summary:The activity of glutathione reductase (GR) was measured in crude mitochondrial fraction isolated from cerebral cortex and basal ganglia of Mongolian gerbils subjected to bilateral carotid occlusion of various duration (1, 2, 3, 5, 10, and 15 min), or reflow (1, 24, and 96 hr) following ischemia (5 or 15 min). Ischemia up to 5 min does not induce changes in GR activity in either structure. Basal ganglia activity is halved at 10 min and cortical at 15 min of ischemia. In reflow, basal ganglia GR activity is diminished, while cortical GR is transiently reduced at day 1 of reflow. The persistent and profound decrease in GR activity in basal ganglia following ischemia is indicative of the lowered antioxidative capacity of these cells, being possibly related to their greater vulnerability toward ischemia.
ISSN:0885-7490
1573-7365
DOI:10.1007/BF00999540