Effect of Methotrexate on Local Cerebral Blood Flow in Conscious Rats

The effect of methotrexate (MTX) on local cerebral blood flow (l-CBF) was studied with autoradiographic [14C]-iodoantipyrine methods in normal conscious rats. I-CBF was reduced by 30-57% in the rats given MTX (100 mg or 200 mg/body) as compared to that in the saline injected control group, but no do...

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Bibliographic Details
Published in:Japanese Journal of Pharmacology 1988, Vol.48(4), pp.499-501
Main Authors: MIZUSAWA, Shigenori, KONDOH, Yasushi, MURAKAMI, Matsutaro, NAKAMICHI, Hiroyuki, SASAKI, Hiroshi, KOMATSU, Kazuo, TAKAHASHI, Akira, KUDOH, Yasutsugu, WATANABE, Katsuhiro, ONO, Yukihiko, UEMURA, Kazuo
Format: Article
Language:English
Subjects:
Animals
Autoradiography
Biological and medical sciences
Cerebrovascular Circulation - drug effects
Consciousness
Drug toxicity and drugs side effects treatment
Male
Medical sciences
Methotrexate - pharmacology
Pharmacology. Drug treatments
Rats
Rats, Inbred Strains
Toxicity: blood
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Summary:The effect of methotrexate (MTX) on local cerebral blood flow (l-CBF) was studied with autoradiographic [14C]-iodoantipyrine methods in normal conscious rats. I-CBF was reduced by 30-57% in the rats given MTX (100 mg or 200 mg/body) as compared to that in the saline injected control group, but no dose-dependent effect was observed. The mechanism of l-CBF reduction by MTX was discussed.
ISSN:0021-5198
1347-3506
DOI:10.1254/jjp.48.499