Effects of intracoronary infusion of nicardipine during silent ischaemia on myocardial metabolism and function

The effects of an intracoronary infusion of nicardipine (0.2 mg over 10 min) on myocardial substrate uptake and function were studied in 16 patients with coronary artery disease and angina pecloris. Silent ischaemia, demonstrated by myocardial lactate production, was induced twice by pacing below an...

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Bibliographic Details
Published in:European heart journal 1988-12, Vol.9 (suppl-N), p.145-150
Main Authors: Hanet, C., Gurné, O., Hue, L., Caucheteux, D., Rousseau, M. F., Pouleur, H.
Format: Article
Language:English
Subjects:
Adult
Aged
Angina Pectoris - diagnosis
Cardiac Catheterization
Coronary Disease - physiopathology
glutamine
Glutamine - blood
Heart - physiopathology
Hemodynamics
Humans
Infusions, Parenteral
lactate
Lactates - blood
Middle Aged
Myocardium - metabolism
nicardipine
Nicardipine - pharmacology
Oxygen Consumption
Silent ischaemia
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Summary:The effects of an intracoronary infusion of nicardipine (0.2 mg over 10 min) on myocardial substrate uptake and function were studied in 16 patients with coronary artery disease and angina pecloris. Silent ischaemia, demonstrated by myocardial lactate production, was induced twice by pacing below anginal threshold. Nicardipine or saline was randomly infused during the first or second pacing. During pacing with nicardipine, no systemic effect was noted but coronary sinus flow increased (+ 18%; P
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/9.suppl_N.145