A model for acute haemodynamic studies in the ascending aorta in pigs

Since data on velocity fields in the ascending aorta downstream of normal aortic valves in pigs have not yet been obtained velocity profiles were visualised using a hot film anemometer needle probe before and after total cardiopulmonary bypass and cold cardioplegic arrest. Furthermore, measurements...

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Bibliographic Details
Published in:Cardiovascular research 1988-07, Vol.22 (7), p.464-471
Main Authors: HASENKAM, J MICHAEL, ØSTERGAARD, JESPER HJORTDAL, PEDERSEN, ERIK MORRE, PAULSEN, PETER KILDEBERG, NYGAARD, HANS, SCHURIZEK, BIRGITTE ASMIN, JOHANNSEN, GUNNAR
Format: Article
Language:English
Subjects:
Anesthesia
Anesthesia depending on type of surgery
Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
Animals
aorta
Aorta - physiology
Biological and medical sciences
Blood Flow Velocity
Cardiac Output
cardioplegia
Cardioplegic Solutions
Cardiopulmonary Bypass
haemodynamics
Heart Arrest, Induced
Hemodynamics
hot film anemometry
Medical sciences
Models, Cardiovascular
pig
Pulse
Rheology
Swine - physiology
Thoracic and cardiovascular surgery. Cardiopulmonary bypass
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Summary:Since data on velocity fields in the ascending aorta downstream of normal aortic valves in pigs have not yet been obtained velocity profiles were visualised using a hot film anemometer needle probe before and after total cardiopulmonary bypass and cold cardioplegic arrest. Furthermore, measurements were made during increased heart rate and cardiac output. A dynamic three dimensional visualisation of velocity fields showed a skewed clockwise rotating velocity profile, developing from peak systole and continuing throughout the systolic deceleration phase. This pattern was consistent regardless of the haemodynamic state. Heart rate was increased to 180 beats·min−1 and cardiac output by a maximum of 91%. It is concluded that the pig model is valuable for haemodynamic studies in the ascending aorta before and after cold cardioplegic arrest and that the velocity profiles found in this study are important basic data for velocity field studies downstream of artificial heart valves implanted in the aortic position.
ISSN:0008-6363
1755-3245
DOI:10.1093/cvr/22.7.464