Loading…
The treatment with differentiation- and apoptosis-inducing agent, vesnarinone, of a patient with oral squamous cell carcinoma
A patient with histopathological recurrent oral cancer with well-differentiated squamous cell carcinoma, was treated with differentiation- and apoptosis-inducing agent, vesnarinone, per os at a dose of 180 mg/day for 56 days and then at a dose of 60 mg/day for 93 days. The vesnarinone administration...
Saved in:
| Published in: | Apoptosis (London) 1997, Vol.2 (3), p.313-318 |
|---|---|
| Main Authors: | , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c320t-8a3cd652a9e20703a8474787cbe17986660e7a73664555f8ee484c6d4f9de6d53 |
|---|---|
| cites | |
| container_end_page | 318 |
| container_issue | 3 |
| container_start_page | 313 |
| container_title | Apoptosis (London) |
| container_volume | 2 |
| creator | Sato, M Harada, K Yura, Y Azuma, M Kawamata, H Iga, H Tsujimoto, H Yoshida, H Adachi, M |
| description | A patient with histopathological recurrent oral cancer with well-differentiated squamous cell carcinoma, was treated with differentiation- and apoptosis-inducing agent, vesnarinone, per os at a dose of 180 mg/day for 56 days and then at a dose of 60 mg/day for 93 days. The vesnarinone administration caused complete remission of the tumour. It has been found by immunohistochemical staining and PCR-SSCP analysis that the recurrent tumour has wild type p53 gene and relative high level of LeY expression as well as DNA fragmentation in the cancer cells, as assessed by nick-end labelling. These findings suggest that the cure of oral squamous cell carcinoma observed in this case might be associated with induction of differentiation and apoptosis of cancer cells by vesnarinone. |
| doi_str_mv | 10.1023/A:1026493205097 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_78765411</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>78765411</sourcerecordid><originalsourceid>FETCH-LOGICAL-c320t-8a3cd652a9e20703a8474787cbe17986660e7a73664555f8ee484c6d4f9de6d53</originalsourceid><addsrcrecordid>eNpdkctLxDAQxoMovs_eJHjwZN1k86y3ZfEFC14UvJWxnWpkm9SkVTz4vxtxUZQ5zAR-8_FNPkIOODvlbComs7PctCzFlClWmjWyzZURhTbqfj3PQrPCcqu2yE5Kz4wxYYXcJFtcaqmVlNvk4_YJ6RARhg79QN_c8EQb17YY89PB4IIvKPiGQh_6ISSXCuebsXb-kcJjZk7oKyYP0fng8YSGlgLt896PWoiwpOllhC6Mida4XNIaYhYIHeyRjRaWCfdXfZfcXZzfzq-Kxc3l9Xy2KOp82FBYEHWj1RRKnDLDBFhppLGmfkBuSqu1ZmjACK2lUqq1iNLKWjeyLRvUjRK75Phbt4_hZcQ0VJ1LX1bAY3ZVZa38HZxn8Ogf-BzG6LO3ymjBmM6Vock3VMeQUsS26qPrIL5XnFVfsVSz6k8seeNwJTs-dNj88qscxCdNzoiQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>763006060</pqid></control><display><type>article</type><title>The treatment with differentiation- and apoptosis-inducing agent, vesnarinone, of a patient with oral squamous cell carcinoma</title><source>Springer Nature</source><creator>Sato, M ; Harada, K ; Yura, Y ; Azuma, M ; Kawamata, H ; Iga, H ; Tsujimoto, H ; Yoshida, H ; Adachi, M</creator><creatorcontrib>Sato, M ; Harada, K ; Yura, Y ; Azuma, M ; Kawamata, H ; Iga, H ; Tsujimoto, H ; Yoshida, H ; Adachi, M</creatorcontrib><description>A patient with histopathological recurrent oral cancer with well-differentiated squamous cell carcinoma, was treated with differentiation- and apoptosis-inducing agent, vesnarinone, per os at a dose of 180 mg/day for 56 days and then at a dose of 60 mg/day for 93 days. The vesnarinone administration caused complete remission of the tumour. It has been found by immunohistochemical staining and PCR-SSCP analysis that the recurrent tumour has wild type p53 gene and relative high level of LeY expression as well as DNA fragmentation in the cancer cells, as assessed by nick-end labelling. These findings suggest that the cure of oral squamous cell carcinoma observed in this case might be associated with induction of differentiation and apoptosis of cancer cells by vesnarinone.</description><identifier>ISSN: 1360-8185</identifier><identifier>EISSN: 1573-675X</identifier><identifier>DOI: 10.1023/A:1026493205097</identifier><identifier>PMID: 14646544</identifier><language>eng</language><publisher>Netherlands: Springer Nature B.V</publisher><subject>Apoptosis ; Skin cancer</subject><ispartof>Apoptosis (London), 1997, Vol.2 (3), p.313-318</ispartof><rights>Chapman and Hall 1997</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c320t-8a3cd652a9e20703a8474787cbe17986660e7a73664555f8ee484c6d4f9de6d53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14646544$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sato, M</creatorcontrib><creatorcontrib>Harada, K</creatorcontrib><creatorcontrib>Yura, Y</creatorcontrib><creatorcontrib>Azuma, M</creatorcontrib><creatorcontrib>Kawamata, H</creatorcontrib><creatorcontrib>Iga, H</creatorcontrib><creatorcontrib>Tsujimoto, H</creatorcontrib><creatorcontrib>Yoshida, H</creatorcontrib><creatorcontrib>Adachi, M</creatorcontrib><title>The treatment with differentiation- and apoptosis-inducing agent, vesnarinone, of a patient with oral squamous cell carcinoma</title><title>Apoptosis (London)</title><addtitle>Apoptosis</addtitle><description>A patient with histopathological recurrent oral cancer with well-differentiated squamous cell carcinoma, was treated with differentiation- and apoptosis-inducing agent, vesnarinone, per os at a dose of 180 mg/day for 56 days and then at a dose of 60 mg/day for 93 days. The vesnarinone administration caused complete remission of the tumour. It has been found by immunohistochemical staining and PCR-SSCP analysis that the recurrent tumour has wild type p53 gene and relative high level of LeY expression as well as DNA fragmentation in the cancer cells, as assessed by nick-end labelling. These findings suggest that the cure of oral squamous cell carcinoma observed in this case might be associated with induction of differentiation and apoptosis of cancer cells by vesnarinone.</description><subject>Apoptosis</subject><subject>Skin cancer</subject><issn>1360-8185</issn><issn>1573-675X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNpdkctLxDAQxoMovs_eJHjwZN1k86y3ZfEFC14UvJWxnWpkm9SkVTz4vxtxUZQ5zAR-8_FNPkIOODvlbComs7PctCzFlClWmjWyzZURhTbqfj3PQrPCcqu2yE5Kz4wxYYXcJFtcaqmVlNvk4_YJ6RARhg79QN_c8EQb17YY89PB4IIvKPiGQh_6ISSXCuebsXb-kcJjZk7oKyYP0fng8YSGlgLt896PWoiwpOllhC6Mida4XNIaYhYIHeyRjRaWCfdXfZfcXZzfzq-Kxc3l9Xy2KOp82FBYEHWj1RRKnDLDBFhppLGmfkBuSqu1ZmjACK2lUqq1iNLKWjeyLRvUjRK75Phbt4_hZcQ0VJ1LX1bAY3ZVZa38HZxn8Ogf-BzG6LO3ymjBmM6Vock3VMeQUsS26qPrIL5XnFVfsVSz6k8seeNwJTs-dNj88qscxCdNzoiQ</recordid><startdate>1997</startdate><enddate>1997</enddate><creator>Sato, M</creator><creator>Harada, K</creator><creator>Yura, Y</creator><creator>Azuma, M</creator><creator>Kawamata, H</creator><creator>Iga, H</creator><creator>Tsujimoto, H</creator><creator>Yoshida, H</creator><creator>Adachi, M</creator><general>Springer Nature B.V</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7RQ</scope><scope>7TK</scope><scope>7TM</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>1997</creationdate><title>The treatment with differentiation- and apoptosis-inducing agent, vesnarinone, of a patient with oral squamous cell carcinoma</title><author>Sato, M ; Harada, K ; Yura, Y ; Azuma, M ; Kawamata, H ; Iga, H ; Tsujimoto, H ; Yoshida, H ; Adachi, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c320t-8a3cd652a9e20703a8474787cbe17986660e7a73664555f8ee484c6d4f9de6d53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Apoptosis</topic><topic>Skin cancer</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sato, M</creatorcontrib><creatorcontrib>Harada, K</creatorcontrib><creatorcontrib>Yura, Y</creatorcontrib><creatorcontrib>Azuma, M</creatorcontrib><creatorcontrib>Kawamata, H</creatorcontrib><creatorcontrib>Iga, H</creatorcontrib><creatorcontrib>Tsujimoto, H</creatorcontrib><creatorcontrib>Yoshida, H</creatorcontrib><creatorcontrib>Adachi, M</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Career & Technical Education Database</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Apoptosis (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sato, M</au><au>Harada, K</au><au>Yura, Y</au><au>Azuma, M</au><au>Kawamata, H</au><au>Iga, H</au><au>Tsujimoto, H</au><au>Yoshida, H</au><au>Adachi, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The treatment with differentiation- and apoptosis-inducing agent, vesnarinone, of a patient with oral squamous cell carcinoma</atitle><jtitle>Apoptosis (London)</jtitle><addtitle>Apoptosis</addtitle><date>1997</date><risdate>1997</risdate><volume>2</volume><issue>3</issue><spage>313</spage><epage>318</epage><pages>313-318</pages><issn>1360-8185</issn><eissn>1573-675X</eissn><abstract>A patient with histopathological recurrent oral cancer with well-differentiated squamous cell carcinoma, was treated with differentiation- and apoptosis-inducing agent, vesnarinone, per os at a dose of 180 mg/day for 56 days and then at a dose of 60 mg/day for 93 days. The vesnarinone administration caused complete remission of the tumour. It has been found by immunohistochemical staining and PCR-SSCP analysis that the recurrent tumour has wild type p53 gene and relative high level of LeY expression as well as DNA fragmentation in the cancer cells, as assessed by nick-end labelling. These findings suggest that the cure of oral squamous cell carcinoma observed in this case might be associated with induction of differentiation and apoptosis of cancer cells by vesnarinone.</abstract><cop>Netherlands</cop><pub>Springer Nature B.V</pub><pmid>14646544</pmid><doi>10.1023/A:1026493205097</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1360-8185 |
| ispartof | Apoptosis (London), 1997, Vol.2 (3), p.313-318 |
| issn | 1360-8185 1573-675X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_78765411 |
| source | Springer Nature |
| subjects | Apoptosis Skin cancer |
| title | The treatment with differentiation- and apoptosis-inducing agent, vesnarinone, of a patient with oral squamous cell carcinoma |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T16%3A11%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=The%20treatment%20with%20differentiation-%20and%20apoptosis-inducing%20agent,%20vesnarinone,%20of%20a%20patient%20with%20oral%20squamous%20cell%20carcinoma&rft.jtitle=Apoptosis%20(London)&rft.au=Sato,%20M&rft.date=1997&rft.volume=2&rft.issue=3&rft.spage=313&rft.epage=318&rft.pages=313-318&rft.issn=1360-8185&rft.eissn=1573-675X&rft_id=info:doi/10.1023/A:1026493205097&rft_dat=%3Cproquest_cross%3E78765411%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c320t-8a3cd652a9e20703a8474787cbe17986660e7a73664555f8ee484c6d4f9de6d53%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=763006060&rft_id=info:pmid/14646544&rfr_iscdi=true |