Intracerebral xenografts: Sertoli cells to the rescue?

In this issue, Sanberg and collaborators propose the intracerebral cotransplantation of Sertoli cells to decrease, if not abolish, the microglial response that results from the implantation of bovine adrenal chromaffin cells into the intact rat striatum. This introductory report outlines an interest...

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Bibliographic Details
Published in:Nature biotechnology 1996-12, Vol.14 (13), p.1650-1651
Main Authors: Senut, Marie-Claude, Suhr, Steven T, Gage, Fred H
Format: Article
Language:English
Subjects:
Agriculture
analysis
Animals
Bioinformatics
Biomedical and Life Sciences
Biomedical Engineering/Biotechnology
Biomedicine
Biotechnology
Brain
Cattle
Chromaffin Cells - immunology
Chromaffin Cells - transplantation
Corpus Striatum - surgery
fas Receptor - immunology
Graft Rejection - prevention & control
Life Sciences
Male
Parkinson Disease - therapy
Rats
Sertoli Cells - immunology
Sertoli Cells - transplantation
Transplantation, Heterologous - immunology
Transplantation, Heterotopic - immunology
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Summary:In this issue, Sanberg and collaborators propose the intracerebral cotransplantation of Sertoli cells to decrease, if not abolish, the microglial response that results from the implantation of bovine adrenal chromaffin cells into the intact rat striatum. This introductory report outlines an interesting approach to specific and local suppression of the inflammatory immune response to cerebral xenografts, without having to neutralize the entire host immune system through the use of pharmacological immune suppressors.
ISSN:1087-0156
1546-1696
DOI:10.1038/nbt1296-1650