Optimal metabolic conditions during fluorine-18 fluorodeoxyglucose imaging : a comparative study using different protocols

Positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (FDG) can identify viable myocardium in patients with coronary artery disease. Recently, FDG imaging with single-photon emission tomography (SPET) and 511-keV collimators has been described. To obtain optimal image quality in all...

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Bibliographic Details
Published in:European Journal of Nuclear Medicine 1997, Vol.24 (1), p.35-41
Main Authors: BAX, J. J, VEENING, M. A, VISSER, F. C, VAN LINGEN, A, HEINE, R. J, CORNEL, J. H, VISSER, C. A
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Blood Glucose - metabolism
Cardiovascular system
Coronary Disease - diagnostic imaging
Coronary Disease - metabolism
Deoxyglucose - analogs & derivatives
Female
Fluorine Radioisotopes
Fluorodeoxyglucose F18
Glucose Clamp Technique
Glucose Tolerance Test
Heart - diagnostic imaging
Humans
Hypolipidemic Agents
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Pyrazines
Radionuclide investigations
Tomography, Emission-Computed, Single-Photon - methods
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Summary:Positron emission tomography (PET) with fluorine-18 fluorodeoxyglucose (FDG) can identify viable myocardium in patients with coronary artery disease. Recently, FDG imaging with single-photon emission tomography (SPET) and 511-keV collimators has been described. To obtain optimal image quality in all patients, cardiac FDG studies should be performed during hyperinsulinaemic glucose clamping. It has been suggested that FDG imaging after the administration of a nicotinic acid derivative may yield comparable image quality to clamping. We studied eight patients and compared the image quality of cardiac FDG SPET studies after oral glucose loading, after administration of a nicotinic acid derivative (acipimox, 250 mg orally) and during hyperinsulinaemic glucose clamping. The image quality was expressed as the myocardial to blood pool (M/B) activity ratio, which is used as a measure of the target-to-background ratio The M/B ratios were comparable after clamping and acipimox (2.8+/-0.8 vs 2.9+/-0.7), whereas the M/B ratio was lower after oral glucose loading (2.2+/-0.3, P
ISSN:0340-6997
1619-7089
DOI:10.1007/BF01728306