Outcome of sextant biopsy according to gland volume

To reassess positive rate of sextant biopsy according to gland size. We evaluated 1974 consecutive men with systematic sextant biopsy, among whom we examined biopsy yield according to gland-volume intervals of 10 cc. Decreasing yield of sextant biopsy is strongly associated with increasing gland vol...

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Bibliographic Details
Published in:Urology (Ridgewood, N.J.) N.J.), 1997, Vol.49 (1), p.55-59
Main Authors: Karakiewicz, Pierre I., Bazinet, Michel, Aprikian, Armen G., Trudel, Claude, Aronson, Samuel, Nachabé, Mahmoud, Péloquint, François, Dessureault, Jean, Goyal, Michelle S., Bégin, Louis R., Elhilali, Mostafa M.
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
Biological and medical sciences
Biopsy - methods
Humans
Investigative techniques, diagnostic techniques (general aspects)
Male
Medical sciences
Middle Aged
Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques
Predictive Value of Tests
Prospective Studies
Prostate - pathology
Prostatic Neoplasms - pathology
Urinary system
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Summary:To reassess positive rate of sextant biopsy according to gland size. We evaluated 1974 consecutive men with systematic sextant biopsy, among whom we examined biopsy yield according to gland-volume intervals of 10 cc. Decreasing yield of sextant biopsy is strongly associated with increasing gland volume ( P 0.05) throughout the range of gland-volume intervals. Our findings suggest that gland size represents an important determinant contributing to the yield of sextant biopsy in men at risk of harboring a nonpalpable, isoechoic cancer. Consequently, an individualized sector biopsy approach, based on prostate volume, may warrant consideration because it may ensure superior detection of clinically significant disease among all men at risk, regardless of prostate size.
ISSN:0090-4295
1527-9995
DOI:10.1016/S0090-4295(96)00360-3