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Role of Macrophages in the Candidacidal Activity of Liposomal Amphotericin B
The role of macrophage activation in the candidacidal activity of liposome-incorporated (L) amphotericin B was investigated. Macrophages treated with L-amphotericin B killed Candida albicans more effectively than did macrophages treated with free (F) amphotericin B. However, macrophages treated with...
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| Published in: | The Journal of infectious diseases 1997-01, Vol.175 (1), p.214-217 |
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| Main Authors: | , , , , |
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| Language: | English |
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| container_end_page | 217 |
| container_issue | 1 |
| container_start_page | 214 |
| container_title | The Journal of infectious diseases |
| container_volume | 175 |
| creator | Mehta, Reeta T. Poddar, Sourav Kalidas, Mamta Gomez-Flores, Ricardo Dulski, Kim |
| description | The role of macrophage activation in the candidacidal activity of liposome-incorporated (L) amphotericin B was investigated. Macrophages treated with L-amphotericin B killed Candida albicans more effectively than did macrophages treated with free (F) amphotericin B. However, macrophages treated with neither F- nor L-amphotericin B killed amphotericin B-resistant Candida tropicalis. In vivo stimulation of macrophages by intraperitoneal administration of thioglycollate, Freund's complete adjuvant, or heat-killed C. albicans followed by in vitro treatment with for L-amphotericin B, did not enhance their candidacidal activity. Intravenous administration of F- or L-amphotericin B did not augment the candidacidal activity of macrophages sensitized in vivo; however, sensitized macrophages showed enhanced killing compared with resident unstimulated cells. These studies suggest that macrophage-mediated enhancement of C. albicans killing may be due to uptake, transport, and delivery of L-amphotericin B to infected sites rather than to macrophage activation. |
| doi_str_mv | 10.1093/infdis/175.1.214 |
| format | article |
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Macrophages treated with L-amphotericin B killed Candida albicans more effectively than did macrophages treated with free (F) amphotericin B. However, macrophages treated with neither F- nor L-amphotericin B killed amphotericin B-resistant Candida tropicalis. In vivo stimulation of macrophages by intraperitoneal administration of thioglycollate, Freund's complete adjuvant, or heat-killed C. albicans followed by in vitro treatment with for L-amphotericin B, did not enhance their candidacidal activity. Intravenous administration of F- or L-amphotericin B did not augment the candidacidal activity of macrophages sensitized in vivo; however, sensitized macrophages showed enhanced killing compared with resident unstimulated cells. These studies suggest that macrophage-mediated enhancement of C. albicans killing may be due to uptake, transport, and delivery of L-amphotericin B to infected sites rather than to macrophage activation.</description><identifier>ISSN: 0022-1899</identifier><identifier>EISSN: 1537-6613</identifier><identifier>DOI: 10.1093/infdis/175.1.214</identifier><identifier>PMID: 8985224</identifier><identifier>CODEN: JIDIAQ</identifier><language>eng</language><publisher>Chicago, IL: The University of Chicago Press</publisher><subject>Amphotericin B - administration & dosage ; Amphotericin B - pharmacology ; Animals ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antifungal agents ; Antifungal Agents - administration & dosage ; Antifungal Agents - pharmacology ; Biological and medical sciences ; Cancer ; Candida albicans ; Candida albicans - drug effects ; Candida albicans - growth & development ; Candida albicans - ultrastructure ; Cell growth ; Cells, Cultured ; Concise Communications ; Cultured cells ; Drug Carriers ; Fungal infections ; Liposomes ; Macrophage Activation ; Macrophages ; Macrophages, Peritoneal - drug effects ; Macrophages, Peritoneal - immunology ; Macrophages, Peritoneal - physiology ; Macrophages, Peritoneal - ultrastructure ; Medical sciences ; Medical treatment ; Mice ; Microscopy, Electron, Scanning ; Pharmacology. Drug treatments</subject><ispartof>The Journal of infectious diseases, 1997-01, Vol.175 (1), p.214-217</ispartof><rights>Copyright 1997 The University of Chicago</rights><rights>1997 by the University of Chicago 1997</rights><rights>1997 INIST-CNRS</rights><rights>Copyright University of Chicago, acting through its Press Jan 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c519t-9d76883bb1b8794e5a63a172b3fdeed1129d2f1fafe149b8bf8916c76e684df53</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,4022,27922,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2542224$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/8985224$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mehta, Reeta T.</creatorcontrib><creatorcontrib>Poddar, Sourav</creatorcontrib><creatorcontrib>Kalidas, Mamta</creatorcontrib><creatorcontrib>Gomez-Flores, Ricardo</creatorcontrib><creatorcontrib>Dulski, Kim</creatorcontrib><title>Role of Macrophages in the Candidacidal Activity of Liposomal Amphotericin B</title><title>The Journal of infectious diseases</title><addtitle>J Infect Dis</addtitle><addtitle>J Infect Dis</addtitle><description>The role of macrophage activation in the candidacidal activity of liposome-incorporated (L) amphotericin B was investigated. Macrophages treated with L-amphotericin B killed Candida albicans more effectively than did macrophages treated with free (F) amphotericin B. However, macrophages treated with neither F- nor L-amphotericin B killed amphotericin B-resistant Candida tropicalis. In vivo stimulation of macrophages by intraperitoneal administration of thioglycollate, Freund's complete adjuvant, or heat-killed C. albicans followed by in vitro treatment with for L-amphotericin B, did not enhance their candidacidal activity. Intravenous administration of F- or L-amphotericin B did not augment the candidacidal activity of macrophages sensitized in vivo; however, sensitized macrophages showed enhanced killing compared with resident unstimulated cells. These studies suggest that macrophage-mediated enhancement of C. albicans killing may be due to uptake, transport, and delivery of L-amphotericin B to infected sites rather than to macrophage activation.</description><subject>Amphotericin B - administration & dosage</subject><subject>Amphotericin B - pharmacology</subject><subject>Animals</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antifungal agents</subject><subject>Antifungal Agents - administration & dosage</subject><subject>Antifungal Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cancer</subject><subject>Candida albicans</subject><subject>Candida albicans - drug effects</subject><subject>Candida albicans - growth & development</subject><subject>Candida albicans - ultrastructure</subject><subject>Cell growth</subject><subject>Cells, Cultured</subject><subject>Concise Communications</subject><subject>Cultured cells</subject><subject>Drug Carriers</subject><subject>Fungal infections</subject><subject>Liposomes</subject><subject>Macrophage Activation</subject><subject>Macrophages</subject><subject>Macrophages, Peritoneal - drug effects</subject><subject>Macrophages, Peritoneal - immunology</subject><subject>Macrophages, Peritoneal - physiology</subject><subject>Macrophages, Peritoneal - ultrastructure</subject><subject>Medical sciences</subject><subject>Medical treatment</subject><subject>Mice</subject><subject>Microscopy, Electron, Scanning</subject><subject>Pharmacology. Drug treatments</subject><issn>0022-1899</issn><issn>1537-6613</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqVks1v1DAQxS0EKsvCnQtShCouVbYeO_HHsV0-WmkLEgIVcbGcxGa9JHGwE0T_-3qVZQ-9IA6WJb_fvNHMM0IvAa8AS3ruetu4eA68XMGKQPEILaCkPGcM6GO0wJiQHISUT9GzGHcY44IyfoJOhBQlIcUCbT771mTeZje6Dn7Y6h8mZq7Pxq3J1rpvXKPrdNrsoh7dbzfe7dmNG3z03f61G7Z-NMHVqebyOXpidRvNi8O9RF_fv_uyvso3nz5cry82eV2CHHPZcCYErSqoBJeFKTWjGjipqG2MaQCIbIgFq62BQlaiskICqzkzTBSNLekSvZl9h-B_TSaOqnOxNm2re-OnqLjgPM3H_wlCKZnkaVdL9PoBuPNT6NMQihAqCSWySBCeobSpGIOxagiu0-FOAVb7ONQch0pxKFApjlTy6uA7VZ1pjgWH_Sf99KDrWOvWBt3XyeAvRsqCzNjZjPlp-I-muzj6cOQpBpo-xH7YfNZdHM2fo67DT8U4TTZX374rhsXt7dubS_WR3gPPHrlY</recordid><startdate>199701</startdate><enddate>199701</enddate><creator>Mehta, Reeta T.</creator><creator>Poddar, Sourav</creator><creator>Kalidas, Mamta</creator><creator>Gomez-Flores, Ricardo</creator><creator>Dulski, Kim</creator><general>The University of Chicago Press</general><general>University of Chicago Press</general><general>Oxford University Press</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7T5</scope><scope>H94</scope><scope>M7N</scope><scope>7X8</scope></search><sort><creationdate>199701</creationdate><title>Role of Macrophages in the Candidacidal Activity of Liposomal Amphotericin B</title><author>Mehta, Reeta T. ; Poddar, Sourav ; Kalidas, Mamta ; Gomez-Flores, Ricardo ; Dulski, Kim</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c519t-9d76883bb1b8794e5a63a172b3fdeed1129d2f1fafe149b8bf8916c76e684df53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>Amphotericin B - administration & dosage</topic><topic>Amphotericin B - pharmacology</topic><topic>Animals</topic><topic>Antibiotics. Antiinfectious agents. Antiparasitic agents</topic><topic>Antifungal agents</topic><topic>Antifungal Agents - administration & dosage</topic><topic>Antifungal Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cancer</topic><topic>Candida albicans</topic><topic>Candida albicans - drug effects</topic><topic>Candida albicans - growth & development</topic><topic>Candida albicans - ultrastructure</topic><topic>Cell growth</topic><topic>Cells, Cultured</topic><topic>Concise Communications</topic><topic>Cultured cells</topic><topic>Drug Carriers</topic><topic>Fungal infections</topic><topic>Liposomes</topic><topic>Macrophage Activation</topic><topic>Macrophages</topic><topic>Macrophages, Peritoneal - drug effects</topic><topic>Macrophages, Peritoneal - immunology</topic><topic>Macrophages, Peritoneal - physiology</topic><topic>Macrophages, Peritoneal - ultrastructure</topic><topic>Medical sciences</topic><topic>Medical treatment</topic><topic>Mice</topic><topic>Microscopy, Electron, Scanning</topic><topic>Pharmacology. Drug treatments</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mehta, Reeta T.</creatorcontrib><creatorcontrib>Poddar, Sourav</creatorcontrib><creatorcontrib>Kalidas, Mamta</creatorcontrib><creatorcontrib>Gomez-Flores, Ricardo</creatorcontrib><creatorcontrib>Dulski, Kim</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><jtitle>The Journal of infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mehta, Reeta T.</au><au>Poddar, Sourav</au><au>Kalidas, Mamta</au><au>Gomez-Flores, Ricardo</au><au>Dulski, Kim</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of Macrophages in the Candidacidal Activity of Liposomal Amphotericin B</atitle><jtitle>The Journal of infectious diseases</jtitle><stitle>J Infect Dis</stitle><addtitle>J Infect Dis</addtitle><date>1997-01</date><risdate>1997</risdate><volume>175</volume><issue>1</issue><spage>214</spage><epage>217</epage><pages>214-217</pages><issn>0022-1899</issn><eissn>1537-6613</eissn><coden>JIDIAQ</coden><abstract>The role of macrophage activation in the candidacidal activity of liposome-incorporated (L) amphotericin B was investigated. Macrophages treated with L-amphotericin B killed Candida albicans more effectively than did macrophages treated with free (F) amphotericin B. However, macrophages treated with neither F- nor L-amphotericin B killed amphotericin B-resistant Candida tropicalis. In vivo stimulation of macrophages by intraperitoneal administration of thioglycollate, Freund's complete adjuvant, or heat-killed C. albicans followed by in vitro treatment with for L-amphotericin B, did not enhance their candidacidal activity. Intravenous administration of F- or L-amphotericin B did not augment the candidacidal activity of macrophages sensitized in vivo; however, sensitized macrophages showed enhanced killing compared with resident unstimulated cells. 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| identifier | ISSN: 0022-1899 |
| ispartof | The Journal of infectious diseases, 1997-01, Vol.175 (1), p.214-217 |
| issn | 0022-1899 1537-6613 |
| language | eng |
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| source | Oxford Journals Online |
| subjects | Amphotericin B - administration & dosage Amphotericin B - pharmacology Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antifungal agents Antifungal Agents - administration & dosage Antifungal Agents - pharmacology Biological and medical sciences Cancer Candida albicans Candida albicans - drug effects Candida albicans - growth & development Candida albicans - ultrastructure Cell growth Cells, Cultured Concise Communications Cultured cells Drug Carriers Fungal infections Liposomes Macrophage Activation Macrophages Macrophages, Peritoneal - drug effects Macrophages, Peritoneal - immunology Macrophages, Peritoneal - physiology Macrophages, Peritoneal - ultrastructure Medical sciences Medical treatment Mice Microscopy, Electron, Scanning Pharmacology. Drug treatments |
| title | Role of Macrophages in the Candidacidal Activity of Liposomal Amphotericin B |
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