Perspectives on Chemotherapeutic Approaches to Antibiotic-Resistant Bacteria

This paper presents an overview of the potential chemotherapeutic approaches to antibiotic resistance, what those approaches have achieved, and future avenues of exploration. Chemical modifications of existing agent classes, interference with resistance mechanisms, searches for inhibitors of novel t...

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Bibliographic Details
Published in:Clinical infectious diseases 1997-01, Vol.24 (Supplement-1), p.S146-S147
Main Author: KESSLER, R. E
Format: Article
Language:English
Subjects:
Addressing Issues of Antimicrobial Resistance
Anti-Bacterial Agents - pharmacology
Antibacterial agents
Antibiotic resistance
Antibiotics. Antiinfectious agents. Antiparasitic agents
Bacteria
Biological and medical sciences
Chemicals
Chemistry, Pharmaceutical - trends
Drug Industry
Drug Resistance, Microbial
Forecasting
Genetic screening
Gram negative bacteria
Macrolides
Medical sciences
Pharmacology. Drug treatments
Resistance mechanisms
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Summary:This paper presents an overview of the potential chemotherapeutic approaches to antibiotic resistance, what those approaches have achieved, and future avenues of exploration. Chemical modifications of existing agent classes, interference with resistance mechanisms, searches for inhibitors of novel targets, and alternatives to chemotherapy with low-molecular-weight molecules are discussed. The research focusing on novel targets and on alternative approaches is most likely to yield breakthroughs against problem organisms in the future.
ISSN:1058-4838
1537-6591
DOI:10.1093/clinids/24.Supplement_1.S146